Figures index

From

Multi Epitopes Vaccine Prediction against Severe Acute Respiratory Syndrome (SARS) Coronavirus Using Immunoinformatics Approaches

Yassir A. Almofti, Khoubieb Ali Abd-elrahman, Sahar Abd Elgadir Gassmallah, Mohammed Ahmed Salih

American Journal of Microbiological Research. 2018, 6(3), 94-114 doi:10.12691/ajmr-6-3-5
  • Figure 1. Phylogenetic tree of the 131 retrieved strains. The retrieved strains demonstrated divergence in their common ancestors
  • Figure 2. Prediction of B-cell epitopes by different IEDB scales (A- Bepipred linear epitope prediction, B- Emini surface accessibility, C- Kolaskar and Tongaonkar antigenicity prediction). Regions above threshold (red line) are proposed to be a part of B cell epitope while regions below the threshold (red line) are not
  • Figure 3. Position of proposed conserved B cell epitopes in structural level of spike S protein of SARS-CoV. Three epitopes were predicted to interact with B cell. The epitopes showed conservancy, surface accessibility and antigenicity using IEDB software
  • Figure 4. T cell proposed epitopes that interact with MHC-I and/ or MHC-II. (A): The epitopes 47-FRSDTLYLT-55, 195-YVYKGYQPI-203 and 880-FAMQMAYRF-888 were found to interact with both MHC-1 and MHC-II alleles. (B): The epitope 851-MIAAYTAAL-859 interacted with MHC-I alleles while the epitope 782-FNFSQILPD-790 interacted only with MHC-II alleles. The positions of proposed epitopes were shown in the 3D structural level of spike S protein of SARS-CoV