Figure 4. OCCN gauche structures with an intramolecular H-bond for 2-aminoethanol (7) and 2-nitroethanol (9); Conformations 8 and 10 indicate disrupted H-bonds after rotations by approximately 120º about the O-C axes

From

It Is Important to Compute Intramolecular Hydrogen Bonding in Drug Design?

María J. R. Yunta

American Journal of Modeling and Optimization. 2017, 5(1), 24-57 doi:10.12691/ajmo-5-1-3