Figure 3. Structures with an intramolecular hydrogen bond for: (1) 1,2-Ethanediol; (3) Salicylic acid; (5) β-Alanine zwitter ion. Conformations 2, 4, 6 prevent the formation of the intramolecular H-bond and are open for forming intermolecular hydrogen bonds

From

It Is Important to Compute Intramolecular Hydrogen Bonding in Drug Design?

María J. R. Yunta

American Journal of Modeling and Optimization. 2017, 5(1), 24-57 doi:10.12691/ajmo-5-1-3