Figure 2. Superposition of best-scored conformations with (in red) and without (in blue) the bridging water molecules compared with the experimentally observed (in green)

From

How Important is to Account for Water When Modeling Biomolecular Complexes?

María J. R. Yunta

American Journal of Modeling and Optimization. 2015, 3(3), 68-86 doi:10.12691/ajmo-3-3-2