Figure 3. A: H&P staining at low power (100X), Tumor cells form both solid sheets and granular architecture. The background shows tumor necrosis and dense tumor desmoplasia. B: Adenocarcenoma component H&P staining at high power (400X), some tumor cells grow in solid sheets. Individual tumor cells are polygonal with high nucleus/cytoplasm ratio, hyperchromatic nuclei with finely granular, stippled chromatin and scant eosinophilic cytoplasm. Nuclear molding is present. Mitotic figures are frequently seen. Adjacent to the tumor nests are well-formed glands. Tumor cells in these glands have uniform, basally oriented and elongated nuclei. Rare intracytoplasmic mucin vacuole is seen. C: Neuroendocrinecomponent. Synaptophysin is positive in more than 65% of the tumor. D: Ki-67 is used to evaluate the proliferation index of the tumor. It shows strong positive nuclear proliferation in majority of the tumor cells up to 90% of the neuroendocrine carcinoma component.

From

Rare Case of Rectal Mixed Adeno-Neuroendocrine Carcinoma

Aleksander Khudiakov, Mohammed Al-Sadawi, Jia Qin, Michael Haddadin, Stanley Soroka, Angeleque Hartt, Lina Soni, Shalini Arora, Samy I. McFarlane

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