Figure 1. (A) Colonoscopy showing a 5 mm sessile polyp in the sigmoid colon. (B) Low power hematoxylin and eosin stains: Colonic mucosa with ill-defined proliferation of uniform spindle-shaped cells arranged in a haphazard pattern within the lamina propria. (C) High power hematoxylin and eosin stains: Cells show elongated bland nuclei with indistinct cell borders. Edema and mild lymphoplasmacytic infiltration in the lamina propria. (D) On immunohistochemistry Schwann cells showed diffuse and strong nuclear and cytoplasmic positivity for S-100 protein.

From

Colorectal Mucosal Schwann-cell Hamartoma: A Case Report and Review of the Literature

Kristina Loukeris, Elmira Mostafidi

American Journal of Medical Case Reports. 2024, 12(3), 49-55 doi:10.12691/ajmcr-12-3-6