Figure 1. Enhanced permeability and retention (EPR) effect can be applied to 3BP treatment. Crude 3BP is low in molecular weight and may leak through the tumor vascular pores. Conjugation of 3BP with polyethylene glycol (PEG) helps retention of 3BP intravascularly to maintain a prolonged effect of 3BP-induced ATP depletion and oxidative stress therapy

From

Oxidative Stress Therapy for Cancer Using Glycolysis Inhibitors: Towards Improving Therapeutic Outcomes

Salah Mohamed El Sayed

American Journal of Medical and Biological Research. 2018, 6(1), 11-15 doi:10.12691/ajmbr-6-1-3