Figure 3. Hypothetical putative pathways depicting the intertwined signaling crosstalk between the MAPK^p38 and NF-κB pathways. The involvement of upstream and downstream kinases in regulating either pathway is also shown. In addition, the selective inhibition of the MAPK^p38 pathway attenuated the release of pro-inflammatory cytokines, however, it contributes to phosphorylation of IκB-α and subsequent NF-κB activation (see Results section for further details)

From

The Irreversible Inhibition of the MAPK^p38 Pathway Downregulates LPS-augmented Release of Interleukin-Related Inflammatory Cytokines (IL-1β, IL-6): Immune Surveillance Unraveling IκB-α/NF-κB Phosphorylation State-independent Mechanism in vitro

John J Haddad

• Previous
• Figure 3 of 3  (Figures index)