Figure 5. Experimental flowchart. p21 knockdown in breast cancer cells increased cell proliferation and migration, decreased cell sphere formation and cloning formation, triggered the growth of triple-negative breast cancer cells, and weakened the oncolytic effect of the TK-deleted vaccinia virus. shRNA = short hairpin RNA; shp21 = short hairpin RNA targeting p21; TNBC = triple-negative breast cancer; TK = thymidine kinase.

From

Breast Cancer Cells and Impairs the Tumor-Killing Effect of the Vaccinia Virus

Mariam Nafea, Aamna Basheer, Ohud Alkhaibry, Alanoud Alsaedan

American Journal of Medical and Biological Research. 2024, 12(2), 36-44 doi:10.12691/ajmbr-12-2-1