Tables index

From

Modeling and in Silico Analysis for Prediction of Epitopes Vaccine against Norwalk virus from Capsid Protein (VP1) through Reverse Vaccinology

Elsideeq E. M. Eltilib, Yassir A. Almofti, Khoubieb Ali Abd-elrahman, Mashair A. A. Nouri

American Journal of Infectious Diseases and Microbiology. 2020, 8(1), 29-44 doi:10.12691/ajidm-8-1-5
  • Table 1. Retrieved strains of capsid protein (VP1) with their date of collection, accession numbers and geographical regions
  • Table 2. B-cell epitopes prediction from the capsid protein, the position of peptides is according to the position of amino acids in the capsid protein
  • Table 3. The 15 epitopes of the B-cell that overlapped the Bepipred linear epitope prediction, Emini surface accessibility and Kolaskar and Tongaonkar antigenicity prediction tools and further subjected to antigenicity, allergenicity and toxicity. The position of epitopes is according to the position of amino acids in the capsid protein (VP1)
  • Table 4. The 22 epitopes that interacted with MHC-1 from the capsid protein (VP1) of the Norwalk virus that demonstrated antigenicity, nonallergic and nontoxic. The population coverage for each predicted epitope was calculated and election of the proposed epitopes was based on the higher population coverage score. The position of epitopes is according to the position of amino acids in the capsid protein
  • Table 5. The best four proposed epitopes from the capsid protein (VP1) of the Norwalk virus that interacted with MHC class I alleles. The position of epitopes is according to the position of amino acids in the capsid protein
  • Table 6. The 105 epitopes from the capsid protein (VP1) and their interaction with MHC class II. These epitopes demonstrated antigenicity, nonallergic and nontoxic. The population coverage for each predicted epitope was calculated and election of the proposed epitopes was based on the higher population coverage score.
  • Table 7. The best eight epitopes that were proposed as a vaccine candidate from the capsid protein (VP1) of the Norwalk virus and interacted with high affinity with MHC class II alleles. The position of epitopes is according to the position of amino acids in the capsid protein
  • Table 8. The population coverage (PC) of MHC-I and MHC-II proposed epitopes. The population coverage of MHC-I was 80.53%, MHC-II was 99.99% and the combined alleles was 100% for all proposed epitopes )PC: Population Coverage)