Figure 3. B: APOE expression status in AD fibroblasts and HNDF cultured in inflammatory conditions. Effect of different natural compounds on APOE gene expression at mRNA level. Status of APOE gene upon co-treatment of cells with 50 pg/ml of IL1β and 1.0 μg/ml of selected agents, respectively, for 12h and was assessed with 0.7 μg of mRNA by RT-qPCR as described in Materials and Methods section. Significant differences between treatment and control are presented as # p ≤ 0.05, ∆ p ≤ 0.01, * p ≤ 0.001

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Natural Compounds Modulate Apolipoprotein E Gene and Protein Expression in Fibroblasts Derived from Young and Old Female Alzheimer’s Patients

Gabriela N. Lopez, Anna Goc, Matthias Rath, Aleksandra Niedzwiecki

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