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From

Dynamism of Ribosomal Protein RPL28 as Biomarker for Monitoring Epigenetic-initiated-breast-cancer Therapy

Sara Houngu¨¨, Blanche Aguida, Callinice D. Capo-chichi

American Journal of Biomedical Research. 2019, 7(1), 21-26 doi:10.12691/ajbr-7-1-5
  • Figure 1. Nuclear envelope protein lamin A expression in breast normal surface epithelial (BNSE) cells and MCF7-LARFP. All BNSE cells express lamin A as shown in panel A. Breast cancer cells from MCF7 cell line transfected with lamin A-RFP display also lamin A-RFP localization around the nuclear envelope as shown in panel B
  • Figure 2. Decrease in RPL28 as biomarker for an efficient follow-up of anticancer therapy with Suberoyl-Bis-Hydroxamic Acid (SBHA). GATA6 is overexpressed in breast cancer cells. More remarkably MCF7 has higher expression of GATA6 which is slightly reduced after stable transfection of lamin A-RFP or treatment with SBHA for 12h. The reduction of RPL28 was significant after transfection of lamin A-RFP or treatment with SBHA.
  • Figure 3. Cell apoptosis is induced in MCF7 in presence of LA and SBHA. MCF7 transfected with lamin A-RFP (MCF7-LARFP) was treated with DMSO (A) and with Suberoyl-bis-hydroxamic acid ¡°SBHA¡± (B) for 12 h. DMSO did not induce cell death in MCF7-LARFP (A) in contrast to SBHA induced apoptotic cell death (B).