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From

Effect of Sitagliptin and Glimepiride on Glucose Homeostasis and cAMP Levels in Peripheral Tissues of HFD/STZ Diabetic Rats

Mohamed I Saad, Maher A Kamel, Mervat Y Hanafi, Madiha H Helmy, Rowaida R Shehata

American Journal of Biomedical Research. 2014, 2(3), 52-60 doi:10.12691/ajbr-2-3-3
  • Figure 1. Standard curve of cAMP. The abbreviations denote B/B0: sample or standard bound / maximum bound
  • Figure 2. Standard curve of total protein
  • Figure 3. Change in fasting blood glucose (FBG) levels of studied groups during the treatment period (4 weeks). Values are presented as mean ± SE (n = 10). The abbreviations denote Glim: rats treated with glimepiride (0.1 mg/kg), Sita 10: rats treated with sitagliptin (10 mg/kg) and Sita 30: rats treated with sitagliptin (30 mg/kg). a: significantly different from the control group, b: significantly different from the diabetic untreated group, c: significantly different from the Glim group, using ANOVA (LSD), p value < 0.05
  • Figure 4. Serum insulin levels (µIU/ml) and HOMA-IR values of different studied groups at the end of the treatment period (4 weeks). Values are presented as mean ± SE (n = 10). The abbreviations denote Glim: rats treated with glimepiride (0.1 mg/kg), Sita 10: rats treated with sitagliptin (10 mg/kg) and Sita 30: rats treated with sitagliptin (30 mg/kg). a: significantly different from the control group, b: significantly different from the diabetic untreated group, c: significantly different from the Glim group, d: significantly different from the Sita 10 group, using ANOVA (LSD), p value < 0.05
  • Figure 5. Change in blood glucose level (mg/dl) during the oral glucose tolerance test (OGTT) of different studied groups done at the end of the treatment period (4 weeks). Values are presented as mean ± SE (n = 10). The abbreviations denote Glim: rats treated with glimepiride (0.1 mg/kg), Sita 10: rats treated with sitagliptin (10 mg/kg) and Sita 30: rats treated with sitagliptin (30 mg/kg). a: significantly different from the control group, b: significantly different from the diabetic untreated group, c: significantly different from the Glim group, d: significantly different from the Sita 10 group, using ANOVA (LSD), p value < 0.05
  • Figure 6. Cyclic adenosine monophosphate (cAMP) levels (pg/mg protein) in the liver, white adipose tissue (WAT) and brown adipose tissue (BAT) of different studied groups. Values are presented as mean ± SE (n = 10). The abbreviations denote Glim: rats treated with glimepiride (0.1 mg/kg), Sita 10: rats treated with sitagliptin (10 mg/kg) and Sita 30: rats treated with sitagliptin (30 mg/kg). a: significantly different from the control group, b: significantly different from the diabetic untreated group, c: significantly different from the Glim group, d: significantly different from the Sita 10 group, using ANOVA (LSD), p value < 0.05