Open Access Peer-reviewed

Separation of the Enantiomers of Lactide, Lactic Acid Dimer, for a Sustainable Bioplastic Management

Nathalie Berezina1,, Nicolas Landercy1, Pierre-Antoine Mariage2, 3, Benoit Morea2

1Green Chemistry Department, Materia Nova R&D Center, Ghislenghien, Belgium

2R&D Department, Galactic SA, Escanaffles, Belgium

3R&D Department, Green2Chem, Leuze, Belgium

World Journal of Organic Chemistry. 2013, 1(2), 20-23. DOI: 10.12691/wjoc-1-2-3
Published online: August 25, 2017


Despite the small difference in the steric hindrance of the substitutes of the asymmetric carbon of the lactic acid, a way for the desymmetrization of the racemic mixture was discovered. Two possibilities have arisen: the synthesis and further separation of diastereoisomers with the (S)-2-methyl-1-butanol as chiral auxiliary and the kinetic discrimination during the esterification with the (R)-(-)-Myrtenol.


lactide, enantiomeric separation, diastereoisomers, PLA, bioplastics
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