Open Access Peer-reviewed

Various Analytical Methodologies for Determination of Selective α1A Receptor Blocker Tamsulosin Hydrochloride and Its Combinations in Different Matrices

Alankar Shrivastava1,, Pratibha Aggrawal1

1Department of Pharmaceutical Analysis. Tifac-core Innovation square, B.R. Nahata College of Pharmacy, Mandsaur, India

World Journal of Analytical Chemistry. 2013, 1(3), 37-48. DOI: 10.12691/wjac-1-3-3
Published online: August 25, 2017

Abstract

Tamsulosin is a more selective α1A subtype antagonist, which maintains the α-antagonist effect on the prostatic capsule and bladder neck but has less of an effect on the vascular system and blood pressure. It has a better side effect profile than earlier α-adrenergic-receptor antagonists, which were initially developed as antihypertensive agents. Tamsulosin hydrochloride is clinically important drug as far as benign prostatic hyperplasia is concerned. Thus in this review all of the analytical methods reported in the literature are summarized. Different spectrophotometric, chromatographic, electroanalytical and some other types of analytical methods were discussed here. Analytical methods were compared in terms of sensitivity, range, applications and economy. The presented review is helpful for the researchers involved in the development of new analytical methods or formulations of Tamsulosin hydrochloride.

Keywords:

tamsulosin hydrochoride, spectrophotometry, chromatography, analytical methods for tamsulosin hydrochloride, electroanalytical method for tamsulosin hydrochloride
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