Figure 3. CBE inhibits NF-κB p65 phosphorylation and histone H4 acetylation while increasing HDAC3 expression in LPS-stimulated RAW264.7 macrophages. After preincubation with CBE for 1 hour, cells were co-treated with LPS for 1 hour, and proteins were obtained and analyzed with western blotting. Bands were quantified by normalizing to β-actin. n = 3 of independent experiments, bars represent mean and S.D. # P<0.05, ## P<0.01, ### P<0.001 as compared to control (unstimulated cells), * P<0.05, ** P<0.01, *** P<0.001 as compared to only LPS-stimulated cell

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Anti-inflammatory Effects of Proanthocyanidin-rich Cranberry Extract through the Suppression of NF-kB Pathway and Histone Acetylase in RAW 264.7 and Mouse Bone Marrow-derived Macrophages

Seok-Yeong Yu, Jungbae Oh, Justin S. Kim, Young-In Kwon, Emmanouil Apostolidis, Young-Cheul Kim

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