Figure 1. The effects of CBE with either 5% or 15% PAC on NO production and Tnf expression in LPS-stimulated RAW 264.7 macrophages. Cells were preincubated with CBE for 1 hour and co-treated with LPS for 12 hours. The media were collected for NO production (A) and cells were harvested for RT-PCR (B). # P<0.05, ## P<0.01, ### P<0.001 as compared to control (unstimulated cells), * P<0.05, ** P<0.01, *** P<0.001 as compared to only LPS-stimulated cell. Ψ P<0.05, ΨΨ P<0.01, ΨΨΨ P<0.001 as compared to 5% PAC-CBE-treated cells. n = 3 of independent experiments, bars represent mean and S.D : Anti-inflammatory Effects of Proanthocyanidin-rich Cranberry Extract through the Suppression of NF-kB Pathway and Histone Acetylase in RAW 264.7 and Mouse Bone Marrow-derived Macrophages : Science and Education Publishing

Figure 1. The effects of CBE with either 5% or 15% PAC on NO production and Tnfα expression in LPS-stimulated RAW 264.7 macrophages. Cells were preincubated with CBE for 1 hour and co-treated with LPS for 12 hours. The media were collected for NO production (A) and cells were harvested for RT-PCR (B). # P<0.05, ## P<0.01, ### P<0.001 as compared to control (unstimulated cells), * P<0.05, P<0.01, * P<0.001 as compared to only LPS-stimulated cell. Ψ P<0.05, ΨΨ P<0.01, ΨΨΨ P<0.001 as compared to 5% PAC-CBE-treated cells. n = 3 of independent experiments, bars represent mean and S.D

Journal of Food and Nutrition Research. 2021, 9(2), 79-86 doi:10.12691/jfnr-9-2-4