Figure 2. Effects of orally administered aqueous (AD, panels A and B) and ethanol extracts (ED, panels C and D) of decaffeinated coffee on formalin-induced licking in mice. The animals were pretreated orally with vehicle, ED (30, 100 and 300 mg/kg), indomethacin (Indo; 10 mg/kg) or morphine (10 mg/kg) prior to formalin injection. The total time spent licking the hind paw was measured in the first (panels A and C) and second (panels B and D) phases after intraplantar injection of formalin. Each column represents the mean ± S.E.M. (n = 8). The asterisks indicate the following significance level when compared to the control group: ***p < 0.001 (Newman-Keuls)

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Anti-inflammatory and Antinociceptive Activities of Decaffeinated Coffee

Maria Eliza de Castro Moreira, Rosemary Gualberto Fonseca Alvarenga Pereira, Daniele Ferreira Dias, Claudinei Alves da Silva, Thiago Corrêa de Souza, Éderson D’Martin Costa, Bárbara Pereira da Silva, Stella Maris da Silveira Duarte, Alexandre Giusti-Paiva, Marcelo Henrique dos Santos

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