Figure 5. Effect of quercetin on TNF-α-induced ER stress and hepatic insulin resistance in HepG2 cells. TNF-α can induce inflammation and ER stress, as well as insulin resistance, in HepG2 cells. The quercetin treatments in the TNF-α-stimulated HepG2 cells ameliorated hepatic insulin resistance by suppressing the inhibition of the inflammation and ER stress response

From

Defensive Effect of Quercetin against Tumor Necrosis Factor α-induced Endoplasmic Reticulum Stress and Hepatic Insulin Resistance in HepG2 Cells

Jeongjin Park, Woojin Jun, Jeongmin Lee, Ok-Kyung Kim

Journal of Food and Nutrition Research. 2018, 6(8), 518-524 doi:10.12691/jfnr-6-8-6