Figure 2. Silibinin suppresses the NO production through the regulation of iNOS, COX2, and IL-1β proteins. (A) The production of NO in LPS-induced RAW264.7 cells. (B) Western blot analysis of the iNOS in LPS-induced RAW264.7 treated with 0, 15, 30, and 60 κM of silibinin. (C) Time dependent analysis of iNOS protein in LPS-induced RAW 264.7 cells. (D) Western blot analysis of the pro-inflammatory cytokines including COX2 and IL-1β in LPS-induced RAW264.7 cells treated with silibinin


Silibinin Suppresses Mediators of Inflammation through the Inhibition of TLR4-TAK1 Pathway in LPS-induced RAW264.7 Cells

Ji-Hyeon Song, Kui-Jin Kim, Boo-Yong Lee

Journal of Food and Nutrition Research. 2016, 4(8), 515-521 doi:10.12691/jfnr-4-8-5