Figure 9. Fucoxanthin-rich brown algae extract induces lymphocyte proliferation and increases survival rates in the CACC mouse model. Spleen weight was obtained from DSS-induced colitis and CACC mice (p < 0.05; Figure 8A-B). Splenocytes were obtained from CACC mice and separated into 96-well culture plates containing RPMI medium with Con A or LPS. After culturing under 5% CO2 for 48 h at 37°C, T cell and B cell proliferations were determined by MTT assay. (C) FX-BAE induced proliferation of lymphocyte T cells and B cells in CACC mice, the optimal treatments for increased immunity were determined as dosages of 1 or 2.5 g/kg every 2 days. (D) groups treated 1 and 2.5 g/kg of FX-BAE every 2 days exhibited improvements in survival rates from 40% to 60% and from 40% to 70%, respectively, compared with the CACC only group. Curcumin (75 mg/kg every 2 days) was used as a positive control. Data are reported as means ±SD (n = 10 mice/group). Different letters indicate significant differences, with at p < 0.05 : Fucoxanthin-Rich Brown Algae Extract Decreases Inflammation and Attenuates Colitis-associated Colon Cancer in Mice : Science and Education Publishing

Figure 9. Fucoxanthin-rich brown algae extract induces lymphocyte proliferation and increases survival rates in the CACC mouse model. Spleen weight was obtained from DSS-induced colitis and CACC mice (p < 0.05; Figure 8A-B). Splenocytes were obtained from CACC mice and separated into 96-well culture plates containing RPMI medium with Con A or LPS. After culturing under 5% CO₂for 48 h at 37°C,T cell and B cell proliferations were determined by MTT assay. (C) FX-BAE induced proliferation of lymphocyte T cells and B cells in CACC mice, the optimal treatments for increased immunity were determined as dosages of 1 or 2.5 g/kg every 2 days. (D) groups treated 1 and 2.5 g/kg of FX-BAE every 2 days exhibited improvements in survival rates from 40% to 60% and from 40% to 70%, respectively, compared with the CACC only group. Curcumin (75 mg/kg every 2 days) was used as a positive control. Data are reported as means ±SD (n = 10 mice/group). Different letters indicate significant differences, with at p < 0.05

Journal of Food and Nutrition Research. 2016, 4(3), 137-147 doi:10.12691/jfnr-4-3-2