Figure 1. Procedure for administration of fucoxanthin-rich brown algae extract to establish DSS-induced colitis and CACC mouse models. The colitis mouse model was established by treatment with 3% DSS in drinking water for 14 days. (A)Animals were separated into five experimental groups and one positive control group. The control group mice were fed with curcumin (0.8 g/kg/day). Animals in experimental groups were individually fed with FX-BAE at dosages of 1, 2, or 5 g/kg/day from day 8 to day 14. (B) Mice were given a single intraperitoneal injection of AOM (12 mg/kg body weight) at the start of the experiment (week 0) and thereafter, received 2% DSS (wt/wt) in drinking water for 7 days at weeks 3, 6, and 9. For the experiment, CACC induced mice were divided into 5 groups; group 1 was fed with curcumin (75 mg/kg/day) as the positive control; groups 2, 3, and 4 were fed with FX-BAE (0.5, 1, and 2.5 g/kg/per day, respectively. Data are reported as means ±SD (n = 10 mice/group)

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Fucoxanthin-Rich Brown Algae Extract Decreases Inflammation and Attenuates Colitis-associated Colon Cancer in Mice

Zwe-Ling Kong, Ning-Jo Kao, Jia-Yuan Hu, Chien-Sheng Wu

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