Figure 6. GF prevents the inhibition of AMPK and accumulation of lipids caused by high glucose in HepG2 cells. A and B, the phosphorylation of AMPK and ACC was expressed as a percentage of that under control conditions. Data were shown by the means ± SD (n= 3). *P < 0.05 compared with normal glucose control. C and D, GF lowers lipid contents and protects against high-glucose-induced lipid accumulation in HepG2 cells. Intracellular TG and TC contents in cell lysates were expressed as micrograms lipid per milligram protein. Data are the means ± SD (n = 4). *P < 0.05 compared between two groups as indicated. pACC, phosphor-ACC; pAMPK, phosphor-AMPKα


Molecular Mechanism of Action for the Geranyl Flavonoid to Counter Dyslipidemia in Diabetic Milieu

Hai Niu, Ke Li, Limei Ma, Weihong Gong, Wen Huang

Journal of Food and Nutrition Research. 2015, 3(6), 371-378 doi:10.12691/jfnr-3-6-3