Figure 2. Treatment with GF lowers serum and hepatic lipid levels as well as stimulates the phosphorylation of AMPK and ACC in the liver of STZ-induced diabetic LDLR-/- mice. A, GF reduces serum TC and TG levels in diabetic LDLR-/- mice. Serum lipid levels were expressed as the means ± SD (n = 10) in diabetic LDLR-/- mice treated or not treated with GF (150 mg/kg/day for 6 weeks). *P < 0.05 compared between two groups as indicated. B, GF decreases the lipid content in diabetic mouse livers. Liver lipids were expressed as milligrams of lipid per gram protein. Data are the means ± SD (n = 5). Quantitative analysis of phosphorylated AMPK and ACC is expressed as the means ± SD (n =5) in the livers. *P < 0.05 versus untreated diabetic LDLR-/- mice. pACC, phosphor-ACC; pAMPK, phosphor-AMPKα


Molecular Mechanism of Action for the Geranyl Flavonoid to Counter Dyslipidemia in Diabetic Milieu

Hai Niu, Ke Li, Limei Ma, Weihong Gong, Wen Huang

Journal of Food and Nutrition Research. 2015, 3(6), 371-378 doi:10.12691/jfnr-3-6-3