The insoluble fraction of the pulverized sesame powder (commercially available as LipiSmart®), which consisted of lignocellulose and resistant protein as active compounds, has been demonstrated to attenuate postprandial triglyceride (TG) elevation in rats presumably by reducing the intestinal absorption of micellized lipids. The present study aims at evaluating inhibitory effects of the pulverized sesame powder on the postprandial elevation of serum TGs in healthy individuals. A total of 83 normolipidemic healthy participants were exposed and assessed in this randomized, placebo-controlled, double-blind, two-arm crossover study. The participants were randomly allocated to either the pulverized sesame powder-placebo sequence or the placebo-pulverized sesame powder sequence. After an oral intake of 500 mg of the pulverized sesame powder or placebo following a standardized high-fat meal, postprandial concentrations of TG and several other lipidemic parameters were measured. For the per protocol subjects (n=77), no significant differences in postprandial TG responses or other lipidemic parameters were found between treatment arms. However, for the participants who tended to have heightened postprandial responses to dietary fat intake (i.e., baseline-corrected TG level≧83 mg/dL when placebo was ingested), intake of the pulverized sesame powder led to significant reduction of baseline-corrected TG concentration at 6h after meal (37.4 vs. 47.3 mg/dL, p-value=0.03) and incremental area under the curve (iAUC) of TG (409.2 vs. 451.4 mg/dL･h, p-value=0.04). These results suggest that the pulverized sesame powder containing lignocellulose and resistant protein represent a new dietary solution to reduce the postprandial elevation of serum TG for healthy individuals, particularly for those who tend to have heightened postprandial responses to dietary fat intake.
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