, Ramdan Panigoro2, Gaga Irawan Nugraha2, Susi Susanah3, Gemilang Lara Utama4, Mas Rizki A.Asyamsumarno5, Tasnim C61Doctoral Student of Medical Science at Padjadjaran University, Bandung, Indonesia
2Department of Basic Medical Sciences. Faculty of Medicine, Padjadjaran University, Bandung. Indonesia
3Department/KSM of Pediatrics, Faculty of Medicine, University of Padjadjaran, Bandung. Indonesia
4Department of Graduate School of Padjadjaran University, Bandung. Indonesia
5Department of Biomedical Sciences, Faculty of Medicine, Padjadjaran University. Bandung. Indonesia
6Public Health Postgraduate Department, Faculty of Health Sciences, Mandala Waluya University. Kendari. Indonesia
Anemia is one of the current health problems, about 50% of anemia is caused by dengue fever so this situation has become a global problem that harms human health, and the social and economic development of the country. The purpose of this review is to examine the implications of drying and fermentation processing methods, anti-nutrients and iron bioavailability of Moringa leaves on parameters of iron deficiency anemia. The narrative method describes research results based on inclusion criteria through article searches in the Google Scholar, PubMed, and Garuda databases. 54 articles corroborate the claims of the effectiveness of Moringa leaves in the treatment of iron deficiency anemia. consists of 34 preclinical research articles using mouse models. Moringa leaf supplementation as an anti-anemia in iron deficiency anemia rat model can be in the form of extract or dry powder and obtained from different processing methods. Moringa leaves are processed into a dry extract and/or dry powder capable of ameliorating hematological and biochemical parameters in preclinical research. The processing method has an impact on changes in anti-nutritional and iron bioavailability of Moringa leaves which have a positive impact on indicators of iron deficiency anemia.
| [1] | M. Mahdi Zangeneh, M. Pooyanmehr, and A. Zangeneh, “Evaluation of the anti-anemic potential of Glycyrrhiza glabra aqueous extract in Phenylhydrazine-treated rats,” Iran. J Pharmacol Ther, vol. 2017, pp. 1-9, 2017. |
| [2] | N. Petry et al., “The proportion of anemia associated with iron deficiency in low, medium, and high human development index countries: A systematic analysis of national surveys,” Nutrients, vol. 8, no. 11, pp. 1-17, 2016.View Article PubMed |
| [3] | Yulaeka, A. Suwondo, T. Suherni, S. Hadisaputro, and M. C. Anwar, “effect of consuming guava leaves (psidii folium) extract on the level of blood profile in teenage girls at vocational high school of palebon semarang, indonesia,” Belitung Nurs. J., vol. 3, no. 5, pp. 548-554, 2017.View Article |
| [4] | R. Yip, “yip 1994_Iron deficiency_ contemporary scientific issues and international programmatic approaches - PubMed.” J Nutr . 1994 Aug;124(8 Suppl):1479S-1490S., 1994.View Article PubMed |
| [5] | J. Díaz-Castro et al., “Influence of nutritional iron deficiency anemia on DNA stability and lipid peroxidation in rats,” Nutrition, vol. 24, no. 11-12, pp. 1167-1173, 2008.View Article PubMed |
| [6] | P. Aisen, C. Enns, and M. Wessling-Resnick, “Chemistry and biology of eukaryotic iron metabolism,” Int. J. Biochem. Cell Biol., vol. 33, no. 10, pp. 940-959, 2001.View Article PubMed |
| [7] | M. Lesjak and S. K. S. Srai, “Role of dietary flavonoids in iron homeostasis,” Pharmaceuticals, vol. 12, no. 3, pp. 1-21, 2019.View Article PubMed |
| [8] | WHO, The global prevalence of anaemia in 2011. 2011. |
| [9] | WHO and FAO, “Guidelines on food fortification with micronutrients,” Retrieved from http//www.who.int/nutri tion/publi catio ns/guide_ food_forti ficat ion_micro Nutr. ents.pdf., 2006. |
| [10] | J. Carrier, E. Aghdassi, J. Cullen, and J. P. Allard, “Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis,” J. Nutr., vol. 132, no. 10, pp. 3146-3150, 2002.View Article PubMed |
| [11] | Permenkes, peraturan menteri kesehatan republik indonesia nomor 88 tahun 2014 tentang standar tablet tambah darah bagi wanita usia subur dan ibu hamiL, no. 1840. 2014. |
| [12] | K. Jimenez, S. Kulnigg-Dabsch, and C. Gasche, “Management of iron deficiency Anemia,” Gastroenterol. Hepatol., vol. 11, no. 4, pp. 241-250, 2015. |
| [13] | Z. Tolkien, L. Stecher, A. P. Mander, D. I. A. Pereira, and J. J. Powell, “Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: A systematic review and meta-analysis,” PLoS One, vol. 10, no. 2, pp. 1-20, 2015.View Article PubMed |
| [14] | T. Permatasari, D. Briawan, and S. Madanijah, “Efektifitas Program Suplementasi Zat Besi pada Remaja Putri di Kota Bogor,” Media Kesehat. Masy. Indones., vol. 14, no. 1, p. 1, 2018.View Article |
| [15] | A. A. Adedapo, O. M. Mogbojuri, and B. O. Emikpe, “safety evaluations of the aqueous extract of the leaves of moringa oleifera in rats,” J. Med. Plants Res., vol. 3, no. 8, pp. 586-591, 2009,. |
| [16] | T. C. Adias, A. O. Ajugwo, T. Erhabor, and C. U. Nyenke, “Pumpkin Extract (Telfairia occidentalis) on Routine Haematological Parameters in Acetone-Induced Oxidative Stress Albino Rats,” Am. J. Food Sci. Technol., vol. 1, no. 4, pp. 67-69, 2013. |
| [17] | R. Rajeswari, B. Pushpa, … K. N.-K. J. of, and U. 2013, “Dehydration of amaranthus leaves and its quality evaluation.,” Karnataka J. Agric. Sci., vol. 26, no. 26(2), pp. 276-80, 2013. |
| [18] | F. Anwar et al., “Moringa oleifera: A Food Plant with Multiple Medicinal Uses,” Phyther. Res., vol. 22, no. 4, pp. 544-549, 2007. |
| [19] | B. Moyo, P. J. Masika, A. Hugo, and V. Muchenje, “Nutritional characterization of Moringa (Moringa oleifera Lam.) leaves,” African J. Biotechnol., vol. 10, no. 60, pp. 12925-12933, 2011.View Article |
| [20] | A. F. A. Razis, M. D. Ibrahim, and S. B. Kntayya, “Health benefits of Moringa oleifera,” Asian Pacific J. Cancer Prev., vol. 15, no. 20, pp. 8571-8576, 2014.View Article PubMed |
| [21] | L. J. Fuglie, “THE MORINGA TREE A local solution to malnutrition?The miracle tree: Moringa oleifera: natural nutrition for the tropics.,” Nature’s Pharm., no. 221, pp. 22-35, 2003. |
| [22] | K. Thapa, M. Poudel, and P. Adhikari, “Moringa oleifera: A Review Article on Nutritional Properties and its Prospect in the Context of Nepal,” Acta Sci. Agric., vol. 3, no. 11, pp. 47-54, 2019.View Article |
| [23] | N. Z. A. Rani, K. Husain, and E. Kumolosasi, “Moringa genus: A review of phytochemistry and pharmacology,” Front. Pharmacol., vol. 9, no. FEB, pp. 1-26, 2018.View Article PubMed |
| [24] | A. Hamidiyah and R. Hikmah, “Penanggulangan Anemia melalui Kader Kokoa Moringa Oleifera (Komo),” J. Community Engagem. Heal., vol. 1, no. 2, pp. 1-5, 2018.View Article |
| [25] | U. C. A. S. Isnainy, L. Arianti, and D. Rosalia, “Pengaruh Konsumsi Ekstrak Daun Kelor Dan Madu Terhadap Peningkatan Hb Ibu Hamil Di Wilayah Kerja Puskesmas Way Halim Kota Bandar Lampung,” Malahayati Nurs. J., vol. 2, no. 1, pp. 57-67, 2020.View Article |
| [26] | A. Estiyani, A. Suwondo, S. Rahayu, S. Hadisaputro, M. N. Widyawati, and K. A. Susiloretni, “the Effect of Moringa Oleifera Leaves on Change in Blood Profile in Postpartum Mothers,” Belitung Nurs. J., vol. 3, no. 3, pp. 191-197, 2017.View Article |
| [27] | L. Indriani, C. Zaddana, N. M. Nurdin, and J. S. M. Sitinjak, “Pengaruh Pemberian Edukasi Gizi dan Kapsul Serbuk Daun Kelor (Moringa oleifera L.) terhadap Kenaikan Kadar Hemoglobin Remaja Putri di Universitas Pakuan,” Media Pharm. Indones., vol. 2, no. 4, p. 200, 2019.View Article |
| [28] | M. Fitriyaa and W. Wijayanti, “Upaya Peningkatan Kadar Hemoglobin Melalui Suplemen Tepung Daun Kelor Pada Remaja Putri,” Proceeding of The URECOL, pp. 86-94, 2020. |
| [29] | E. Emmanuel and Emmanuel, “Phytochemical and anti-nutritional studies on some commonly consumed fruits in lokoja, kogi state of Nigeria,” Gen. Med. Open, vol. 2, no. 3, pp. 1-5, 2018, doi: 10.15761/gmo.1000135.View Article |
| [30] | A. Pandey, “Moringa Oleifera Lam. (Sahijan) - A Plant with a Plethora of Diverse Therapeutic Benefits: An Updated Retrospection,” Med. Aromat. Plants, vol. 1, no. 1, 2012.View Article |
| [31] | R. I. Bakare, O. A. Magbagbeola, A. I. Akinwande, and O. W. Okunowo, “Nutritional and chemical evaluation of Momordica charantia,” J. Med. Plants Res., vol. 4, no. 21, pp. 2189-2193, 2010. |
| [32] | M. Ali, M. N. Shuja, M. Zahoor, and I. Qadri, “Phytic acid: How far have we come?,” African J. Biotechnol., vol. 9, no. 11, pp. 1551-1554, 2010.View Article |
| [33] | A. B. Sallau, S. B. Mada, S. Ibrahim, and U. Ibrahim, “Effect of boiling, simmering and blanching on the antinutritional content of Moringa oleifera leaves,” Int. J. Food Nutr. Saf., vol. 2, no. 1, pp. 1-6, 2012. |
| [34] | C. Alidou, A. Salifou, J. Djossou, and M. Mohamed, “Roasting effect on anti-nutritional factors of the Moringa oleifera leaves,” vol. 3, no. xxxx, pp. 1554-1564, 2016. |
| [35] | N. N. Umerah, A. I. Asouzu, and J. I. Okoye, “Effect of Processing on the Nutritional Composition of Moringa olifera Leaves and Seeds,” Eur. J. Nutr. Food Saf., vol. 11, no. 3, pp. 124-135, 2019.View Article |
| [36] | A. O. Ademiluyi, O. H. Aladeselu, G. Oboh, and A. A. Boligon, “Drying alters the phenolic constituents, antioxidant properties, α-amylase, and α-glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf,” Food Sci. Nutr., vol. 6, no. 8, pp. 2123-2133, 2018.View Article PubMed |
| [37] | S. Anita, M. Aravindh, and E. Ramya, “Influence of Probioticated Moringa Oleifera Leaf Extract for Treatment of Anaemia Using Animal Model,” Int. Res. J. Pharm., vol. 8, no. 5, pp. 101-107, 2017.View Article |
| [38] | D. D. Gallaher et al., “Iron Bioavailability from Moringa oleifera Leaves Is Very Low | The FASEB Journal,” fasebj, 2017. |
| [39] | A. A. J. Armel, F. N. Edith, and M. C. Moses, “In vitro Protein Digestibility and Iron Bioavailability According to Agro-Ecological Zone and Stage of Maturity of Moringa oleifera Lam Leaves,” European Journal of Nutrition & Food Safety. pp. 90-103, 2020.View Article |
| [40] | R. van der Merwe, J. Kruger, M. G. Ferruzzi, K. G. Duodu, and J. R. N. Taylor, “Improving iron and zinc bioaccessibility through food-to-food fortification of pearl millet with tropical plant foodstuffs (moringa leaf powder, roselle calyces and baobab fruit pulp),” J. Food Sci. Technol., vol. 56, no. 4, pp. 2244-2256, 2019.View Article PubMed |
| [41] | O. Oladeji, K. Taiwo, S. Gbadamosi, B. Oladeji, and M. Ishola, “Studies on Chemical Constituents and Nutrients Bioavailability in Moringa oleifera Leaf and Seed,” J. Sci. Res. Reports, vol. 14, no. 1, pp. 1-12, 2017.View Article |
| [42] | T. Mongwaketse, “Iron and zinc bioaccessibility from African leafy vegetables : implications for nutrition Mini-dissertation submitted in partial fulfilment of the requirements for the degree Master of Science in Nutrition at the Potchefstroom Campus of the North-West Uni,” 2014. |
| [43] | A. Mun’im, M. U. Puteri, S. P. Sari, and Azizahwati, “Anti-anemia effect of standardized extract of moringa oleifera lamk. Leaves on aniline induced rats,” Pharmacogn. J., vol. 8, no. 3, pp. 255-258, 2016.View Article |
| [44] | H. M. Osman, M. E. Shayoub, E. M. Babiker, B. Osman, and A. M. Elhassan, “Effect of Ethanolic Leaf Extract of Moringa oleifera on Aluminum-induced Anemia in White Albino Rats,” vol. 5, no. 4, pp. 255-260, 2012. |
| [45] | S. S. Ameh and O. F. Alafi, “Effect of Ethanol Extract of Moringa Oleifera Leaves in Protecting Anaemia Induced in Rats by Aluminium Chloride,” IOSR J. Biotechnol. Biochem., vol. 4, no. 6, pp. 34-52, 2018. |
| [46] | W. Ricika, “The Effectiveness Of Moringa oleifera L (Moringa oleifera L) Fraction On The Improvement Of Hemoglobine Levels Of Betinine Rat (Rattus norvegicus) Anemia Model Of Iron Deficiency,” Biomedical Journal of Indonesia, vol. 6, no. 3. pp. 63-70, 2020.View Article |
| [47] | A. O. Ajugwo, P. E. Mounbegna, T. S. Kemajou, and V. C. Ofokansi, “Effects of Moringa oleifera leaves extract on haematological parameters of phenylhydrazine anaemia induced wistar rats,” Int. J. Public Heal. Saf., vol. 2, no. 4, pp. 1-4, 2017. |
| [48] | A. Coulibaly, N. B. Gnangoran, J. B. N. Oussou, and M. nahounou Bleyere, “Evaluation of Moringa oleifera Lam leaves (Moringaceae) diets against induced anemia in Wistar rats,” J. Nutr. Food Sci, vol. 2, no. 3, pp. 101-106, 2020. |
| [49] | N. B. Gnangoran, M. N. BLEYERE, J.-B. N. OUSSOU, A. COULIBALY, and P. A. YAPO, “Comparative Effects Between A Total Aqueous Extract and A Diet Enriched with Moringa oleifera Leaves in Wistar Rats with Anemia,” J. Med. Biol. Sci. Res., vol. 6, no. 3, pp. 35-41, 2020.View Article |
| [50] | D. Hermayanti and F. Syafitri, “EFEKTIFITAS EKSTRAK DAUN KELOR (Moringa oleifera lam) DALAM MEMPERBAIKI PROFIL SERUM IRON, SATURASI TRANSFERIN, DAN TOTAL IRON BINDING …,” Herb-Medicine Journal, vol. 3, no. April. pp. 1-5, 2020.View Article |
| [51] | D. Hermayanti, W. Setiawan, and R. M. Azhar, “The Effect Of Moringa Leaf (Moringa Oleifera Lam) And Vitamin C Combination Extract In Improving Anemia Indicators Deficiency Of White Rice Iron Male Diet Low Rice Iron,” Jurnal Saintika Medika, vol. 16, no. 2. pp. 104-114, 2020. |
| [52] | U. D. Indrayani, H. Sarosa, A. Hussaana, and B. Widiyanto, “The Effects Comparisons of Sauropus androgynous, Moringa oleiefera alone and in combination on iron deficiency in anemia rats,” Bangladesh J. Med. Sci., vol. 18, no. 1, pp. 136-140, 2019.View Article |
| [53] | R. Safitri and R. Retnaningsih, “Role Of Moringa Oleifera Leaf Extract In Increasing Hemoglobin Levels In Pregnant Rats With Anemia,” J. Heal. Sci., vol. 14, no. 1, pp. 8-13, 2021.View Article |
| [54] | A. Mun’im et al., “Anti-anemia effect of standardized extract of moringa oleifera lamk. Leaves on aniline induced rats,” Pharmacogn. J., vol. 8, no. 3, pp. 255-258, 2016.View Article |
| [55] | E. Madukwe, A. Ugwuoke, and J. Ezeugwo, “Effectiveness of dry Moringa oleifera leaf powder in treatment of anaemia,” Int. J. Med. Med. Sci., vol. 5, no. 5, pp. 226-228, 2013. |
| [56] | A. Thakur, V. Sharma, and A. Thakur, “An overview of anti-nutritional factors in food,” Int. J. Chem. Stud., no. January, pp. 2472-2479, 2019. |
| [57] | A. Popova and D. Mihaylova, “Antinutrients in Plant-based Foods: A Review,” Open Biotechnol. J., vol. 13, no. 1, pp. 68-76, 2019.View Article |
| [58] | K. O. Soetan and O. E. Oyewole, “The need for adequate processing to reduce the anti- nutritional factors in plants used as human foods and animal feeds : A review,” vol. 3, no. 9. pp. 223-232, 2009. |
| [59] | M. Samtiya, R. E. Aluko, and T. Dhewa, “Plant food anti-nutritional factors and their reduction strategies: an overview,” Food Prod. Process. Nutr., vol. 2, no. 1, pp. 1-14, 2020.View Article |
| [60] | K. W. Waldron, M. L. Parker, and A. C. Smith, “Plant Cell Walls and Food Quality,” Compr. Rev. Food Sci. Food Saf., vol. 2, no. Oliver 1997, pp. 101-119, 2003.View Article PubMed |
| [61] | A. A. Akindahunsi, “EFFECT OF SOME POST-HARVEST TREATMENTS ON THE BIOAVAILABILITY OF ZINC FROM SOME SELECTED TROPICAL VEGETABLES,” La Riv. Ital. Delle Sostanze Grasse, vol. 76, pp. 285-287, 1999. |
| [62] | V. DEWANTO, X. WU, K. K. ADOM, and A. R. H. LIU, “Thermal Processing Enhances the Nutritional Value of Tomatoes by Increasing Total Antioxidant Activity,” J. Agric. Food Chem, vol. 50, pp. 3010-3014, 2002.View Article PubMed |
| [63] | M. H. Lyimo, S. Nyagwegwe, and A. P. Mnkeni, “Investigations on the effect of traditional food processing, preservation and storage methods on vegetable nutrients: A case study in Tanzania,” Plant Foods Hum. Nutr., vol. 41, no. 1, pp. 53-57, 1991.View Article PubMed |
| [64] | T. Baysal, F. Icier, S. Ersus, and H. Yildiz, “Effects of microwave and infrared drying on the quality of carrot and garlic,” Eur. Food Res. Technol., vol. 218, no. 1, pp. 68-73, 2003.View Article |
| [65] | C. Suprihartini, A. Ulilalbab, and F. A. Budiman, “Efek Penambahan Tepung Daun Kelor Pada Fermentasi Tempe Terhadap Kadar Vitamin C Dan N-Amino Tempe Kelor (Pelor),” Heal. J. 1, vol. 12, no. 1, pp. 369-374, 2021. |
| [66] | S. S. Hur, S. W. Choi, D. R. Lee, J. H. Park, and T. H. Chung, “Advanced Effect of Moringa oleifera Bioconversion by Rhizopus oligosporus on the Treatment of Atopic Dermatitis: Preliminary Study,” Evidence-based Complement. Altern. Med., vol. 2018, 2018.View Article PubMed |
| [67] | A. Chawafambira, M. M. Sedibe, A. Mpofu, and M. Achilonu, “Probiotic Potential, Iron and Zinc Bioaccessibility, and Sensory Quality of Uapaca kirkiana Fruit Jam Fermented with Lactobacillus rhamnosus Yoba,” International Journal of Food Science, vol. 2020. 2020.View Article PubMed |
| [68] | A. Djonu, S. Andayani, and H. Nursyam, “Identification of moringa oleifera leaves content fermented by rhizopus oligosporus,” Int. J. Sci. Technol. Res., vol. 7, no. 4, pp. 102-104, 2018. |
| [69] | T. Bhanja, A. Kumari, and R. Banerjee, “Enrichment of phenolics and free radical scavenging property of wheat koji prepared with two filamentous fungi,” Bioresour. Technol., vol. 100, no. 11, pp. 2861-2866, 2009.View Article PubMed |
| [70] | H. Kobayashi et al., “Efficacy and safety of a traditional herbal medicine, hochu-ekki-to in the long-term management of Kikyo (Delicate Constitution) patients with atopic dermatitis: A 6-month, multicenter, double-blind, randomized, placebo-controlled study,” Evidence-based Complement. Altern. Med., vol. 7, no. 3, pp. 367-373, 2010.View Article PubMed |
| [71] | H. Shi, E. Yang, Y. Li, X. Chen, and J. Zhang, “Effect of Solid-State Fermentation on Nutritional Quality of Leaf Flour of the Drumstick Tree (Moringa oleifera Lam.),” Front. Bioeng. Biotechnol., vol. 9, pp. 1-16, 2021.View Article PubMed |
| [72] | T. B. Dey and R. C. Kuhad, “Enhanced production and extraction of phenolic compounds from wheat by solid-state fermentation with Rhizopus oryzae RCK2012,” Biotechnol. Reports, vol. 4, no. 1, pp. 120-127, 2014.View Article PubMed |
| [73] | M. R. Adedayo, J. K. Akintunde, A. Sani, and A. A. Boligon, “Effect of dietary supplement from mono- culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model,” Food Sci Nutr, vol. 6, no. January 2017, pp. 1826-1838, 2018.View Article PubMed |
| [74] | K. Sano and H. Ogawa, “Chapter 4 Hemagglutination ( Inhibition ) Assay,” vol. 1200, pp. 47-52, 2014.View Article PubMed |
| [75] | B. Xie, T. J. Halter, B. M. Borah, and G. H. Nancollas, “Aggregation of calcium phosphate and oxalate phases in the formation of renal stones,” Cryst. Growth Des., vol. 15, no. 1, pp. 204-211, 2015.View Article PubMed |
| [76] | R. S. Kelly et al., “Blood erythrocyte concentrations of cadmium and lead and the risk of B-cell non-Hodgkin’s lymphoma and multiple myeloma: A nested case-control study,” PLoS One, vol. 8, no. 11, 2013.View Article PubMed |
| [77] | N. Panth, K. R. Paudel, and K. Parajuli, “Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease,” Adv. Med., vol. 2016, pp. 1-12, 2016.View Article PubMed |
| [78] | B. G. Forget and H. Franklin Bunn, “Classification of the disorders of hemoglobin,” Cold Spring Harb. Perspect. Med., vol. 3, no. 2, 2013.View Article PubMed |
| [79] | J. K. Akintunde, G. Oboh, and A. A. Akindahunsi, “Inhibition of Key Markers Linked With Spermatogenesis and Cellular ATP by Subchronic Exposure to Leachate in a Rat Model,” Arch. Environ. Contam. Toxicol., vol. 68, no. 1, pp. 159-168, 2015.View Article PubMed |
| [80] | I. Iskandar, V. Hadju, S. As ’ad, and R. Natsir, “Effect of Moringa Oleifera Leaf Extracts Supplementation in Preventing Maternal Anemia and Low-Birth-Weight,” Int. J. Sci. Res. Publ., vol. 5, no. 1, pp. 2250-3153, 2015. |
| [81] | M. Saarela, G. Mogensen, R. Fondén, J. Mättö, and T. Mattila-Sandholm, “Probiotic bacteria: Safety, functional and technological properties,” J. Biotechnol., vol. 84, no. 3, pp. 197-215, 2000.View Article PubMed |
| [82] | K. Tiihonen, T. Suomalainen, S. Tynkkynen, and N. Rautonen, “Effect of prebiotic supplementation on a probiotic bacteria mixture: Comparison between a rat model and clinical trials,” Br. J. Nutr., vol. 99, no. 4, pp. 826-831, 2008.View Article PubMed |
| [83] | S. L. Vilanculos and U. Svanberg, “Degradation of phytate in composite wheat/cassava/sorghum bread by activation of intrinsic cereal phytase,” African J. Food Sci., vol. 15, no. 1, pp. 1-9, 2021.View Article |
| [84] | N. N. Thierry, T. N. Léopold, M. Didier, and F. M. C. Moses, “Effect of Pure Culture Fermentation on Biochemical Composition of Moringa oleifera Lam Leaves Powders,” no. May 2017, 2013.View Article |
| [85] | A. C. Mallillin et al., “Mineral availability and dietary fiber characteristics of Moringa oleifera,” Food Public Heal., vol. 4, no. 5, pp. 242-246, 2014. |
| [86] | R. F. Hurrell, M. Reddy, and J. D. Cook, “Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages,” Br. J. Nutr., vol. 81, no. 4, pp. 289-295, 1999.View Article PubMed |
| [87] | E. Y. Kim, S. K. Ham, M. K. Shigenaga, and O. Han, “Bioactive dietary polyphenolic compounds reduce nonheme iron transport across human intestinal cell monolayers,” J. Nutr., vol. 138, no. 9, pp. 1647-1651, 2008, doi: 10.1093/jn/138.9.1647.View Article PubMed |
| [88] | M. E. Walters, R. Esfandi, and A. Tsopmo, “Potential of food hydrolyzed proteins and peptides to chelate iron or calcium and enhance their absorption,” Foods, vol. 7, no. 10, 2018.View Article PubMed |
| [89] | Y. Li, H. Jiang, and G. Huang, “Protein hydrolysates as promoters of non-haem iron absorption,” Nutrients, vol. 9, no. 6, pp. 1-18, 2017.View Article PubMed |
| [90] | E. O. Silva and A. P. F. R. L. Bracarense, “Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems,” J. Food Sci., vol. 81, no. 6, pp. R1357-R1362, 2016.View Article PubMed |
| [91] | I. O. Igwilo, F. C. Ezeonu, S. C. Udedi, K. I. Ubaoji, N. A. Ozumba, and H. A. Ogbunugafor, “Nutrient composition and anti-nutritional factors in a local cultivar of Moringa oleifera (Lam) flowers,” An Indian J., vol. 7, no. 2, pp. 86-90, 2011. |
| [92] | M. D. Thurber and J. W. Fahey, “NIH Public Access,” vol. 48, no. 3, pp. 1-13, 2010, doi: 10.1080/03670240902794598.Adoption. |
| [93] | E. . Madukwe, A. . Ugwouke, and J. . Ezeugwu, “Effectiveness of dry Moringa oleifera leaf powder in treatment of anaemia,” vol. 5, no. May, pp. 226-228, 2013. |
| [94] | F. W. Nurjanah, S. Hadisaputro, and D. Fatmasari, “Long Bean Leaf Extract for Improving Haematological Status of Female Adolescent with Anemia that Gets Fe Supplementation,” J. Kesehat. Masy., vol. 16, no. 1, pp. 81-87, 2020.View Article |
| [95] | P. Santiago, “Ferrous versus ferric oral iron formulations for the treatment of iron deficiency: A clinical overview,” Sci. World J., vol. 2012, 2012.View Article PubMed |
| [96] | A. E. Shija, S. F. Rumisha, N. M. Oriyo, S. P. Kilima, and J. J. Massaga, “Effect of Moringa Oleifera leaf powder supplementation on reducing anemia in children below two years in Kisarawe District, Tanzania,” Food Sci. Nutr., vol. 7, no. 8, pp. 2584-2594, 2019.View Article PubMed |
| [97] | V. S. Nambiar, K. Patel, C. Gosai, S. Nithya, and R. Desai, “Effect of beta carotene from dehydrated drumstick leaf powder on the haematological indices of non-pregnant non-lactating young women aged 18-25 yrs (preliminary trials).,” Int. J. Pharm. Biol. Arch., vol. 3, no. 3, pp. 646-653, 2012. |
| [98] | S. Gebremedhin, “Effect of a single high dose vitamin A supplementation on the hemoglobin status of children aged 6-59 months: Propensity score matched retrospective cohort study based on the data of Ethiopian Demographic and Health Survey 2011,” BMC Pediatr., vol. 14, no. 1, 2014.View Article PubMed |
| [99] | F. B. Michelazzo, J. M. Oliveira, J. Stefanello, L. A. Luzia, and P. H. C. Rondó, “The influence of vitamin A supplementation on iron status,” Nutrients, vol. 5, no. 11, pp. 4399-4413, 2013.View Article PubMed |
| [100] | K. Petersson et al., “Acoustofluidic hematocrit determination,” Anal. Chim. Acta, vol. xxx, pp. 1-6, 2017. |
| [101] | V. S. Nambiar and S. Seshadri, “Bioavailability trials of β-carotene from fresh and dehydrated drumstick leaves (Moringa oleifera) in a rat model,” pp. 83-95, 2001. |
| [102] | Y. Astuti, “Hubungan antara Asupan Protein, Zat Besi dan Vitamin C dengan Kadar Hb pada Anak Umur (7-15) tahun di Desa Sidoharjo, Samigaluh, Kulon Progo,” Mutiara Med., vol. 10, no. 2, pp. 172-179, 2010. |
| [103] | Z. Taimeh et al., “Erythrocyte aging as a mechanism of anemia and a biomarker of device thrombosis in continuous-flow left ventricular assist devices,” J. Hear. Lung Transplant., vol. 36, no. 6, pp. 625-632, 2017.View Article PubMed |
| [104] | E. Yabalak, Z. Emire, A. O. Adıgüzel, S. Könen Adıgüzel, and A. M. Gizir, “Wide-scale evaluation of Origanum munzurense Kit Tan & Sorger using different extraction techniques: Antioxidant capacity, chemical compounds, trace element content, total phenolic content, antibacterial activity and genotoxic effect,” Flavour Fragr. J., vol. 35, no. 4, pp. 394-410, 2020.View Article |
| [105] | S. Susanty, “Metode Ekstraksi Untuk Perolehan Kandungan Flavanoid Tertinggi Dari Ekstrak Daun Kelor (Moringa oleifera Lam),” J. Konversi, vol. 8, no. 2, pp. 31-36, 2019. |
| [106] | I. Oduro, W. O. Ellis, and D. Owusu, “Nutritional potential of two leafy vegetables: Moringa oleifera and Ipomoea batatas leaves,” Sci. Res. Essays, vol. 3, no. 2, pp. 057-060, 2008. |
| [107] | D. Hastuty, V. Hadju, and A. Ariyandy, “The effect of giving extracted moringa oleifera leaves plus Royal Jelly supplement on erythrocyte index of anemia pregnant women in Takalar District,” European Journal of Molecular and Clinical Medicine, vol. 7, no. 6. pp. 701-710, 2020. |
| [108] | W. Bhalchandra, Y. A. Alqadhi, and A. S. Ninawe, “Ameliorative Role of Bee Honey and Royal Jelly Against Cisplatin Induced Alteration in Hematological Parameters in Male Wister Albino Rat,” Int. J. Pharm. Pharm. Sci., vol. 10, no. 4, p. 110, 2018.View Article |
