Figure 3. Micronuclei frequency in peripheral blood reticulocytes in male mice supplemented with oral ascorbic acid. The groups 100, 150 and 225 mg/kg/day showed a significant increase in the micronucleus count during all experimental time (4 weeks). No difference was observed in groups 0 and 50 mg/kg during all experimental time. ANOVA and Tukey’s Multiple Comparison Test. *P≤0.05 (administration time vs T0), a p ≤ 0.05 (100, 150 and 225 mg/kg vs 0 and 50 mg/kg), b p ≤ 0.05 (150 and 225 mg/kg vs 100, 50 and 0 mg/kg), c p ≤ 0.05 (100 mg/kg vs 50 and 0). Pearson’s correlation index MN: 225 mg/kg r2= 0.9230 : Genotoxic Effects of Oral Ascorbate in Healthy Mice: Evaluation of DNA Single-strand Breaks and Micronucleus : Science and Education Publishing

Figure 3. Micronuclei frequency in peripheral blood reticulocytes in male mice supplemented with oral ascorbic acid. The groups 100, 150 and 225 mg/kg/day showed a significant increase in the micronucleus count during all experimental time (4 weeks). No difference was observed in groups 0 and 50 mg/kg during all experimental time. ANOVA and Tukey’s Multiple Comparison Test. *P≤0.05 (administration time vs T0), ^ap ≤ 0.05 (100, 150 and 225 mg/kg vs 0 and 50 mg/kg), ^bp ≤ 0.05 (150 and 225 mg/kg vs 100, 50 and 0 mg/kg), ^cp ≤ 0.05 (100 mg/kg vs 50 and 0). Pearson’s correlation index MN: 225 mg/kg r²= 0.9230

Journal of Food and Nutrition Research. 2022, 10(8), 578-583 doi:10.12691/jfnr-10-8-6