Figure 5. Eucommia ulmoides (EU) regulates LXA4 and inflammatory responses induced by monoiodoacetate (MIA). (A-D) Levels of TNF-, IL-6, IL-1β (A), PGE2 (B), CTXII (C), and LXA4 (D) in intra-articular lavage fluid (IALF) were determined by enzyme-linked immunosorbent assay. Values are expressed as the mean ± SEM. One-way ANOVA was performed followed by Dunnett’s multiple comparisons test. LXA4, Lipoxin A4; TNF-, tumor necrosis factor-alpha; IL-6, Interleukin-16; IL-1βInterleukin-1beta; PGE2, Prostaglandin E2; CTXII, C-telopeptide fragments of type II collagen.Pound keys (#) indicate statistical significance (#P < 0.05, ###P < 0.005) relative to Sham operated group. Asterisks (*) indicate statistical significance (*P < 0.05, **P < 0.05, ***P < 0.005) comparing EU-treated groups relative to MIA injected group : Eucommia ulmoides Prevents Articular Cartilage Destruction via FPR2-LXA4 in the Rat Monoiodoacetate Model of Osteoarthritis : Science and Education Publishing

Figure 5. Eucommia ulmoides (EU) regulates LXA₄ and inflammatory responses induced by monoiodoacetate (MIA). (A-D) Levels of TNF-α, IL-6, IL-1β (A), PGE2 (B), CTXII (C), and LXA₄ (D) in intra-articular lavage fluid (IALF) were determined by enzyme-linked immunosorbent assay. Values are expressed as the mean ± SEM. One-way ANOVA was performed followed by Dunnett’s multiple comparisons test. LXA_4,Lipoxin A₄; TNF-α, tumor necrosis factor-alpha; IL-6, Interleukin-16; IL-1βInterleukin-1beta; PGE2, Prostaglandin E2; CTXII, C-telopeptide fragments of type II collagen.Pound keys (#) indicate statistical significance (#P < 0.05, ###P < 0.005) relative to Sham operated group. Asterisks () indicate statistical significance (P < 0.05, P < 0.05, *P < 0.005) comparing EU-treated groups relative to MIA injected group

Journal of Food and Nutrition Research. 2022, 10(4), 313-320 doi:10.12691/jfnr-10-4-8