Figure 1. Effects of Eucommia ulmoides (EU) on monoiodoacetate (MIA)-induced osteoarthritis (OA) in rats. (A) Pain behavior was assessed as mechanical hyperalgesia, measured with a dynamic plantar esthesiometer, and was quantified as paw withdrawal latency (right) (n = 10 per group). (B, C) Experimental OA was examined by scoring of OA parameters, including articular cartilage destruction (OARSI grade) (B) and safranin-O staining (C) (n = 10). Scale bar = 200 m. Values are expressed as the mean ± SEM. One-way ANOVA was performed followed by Dunnett’s multiple comparisons test. OARSI, Osteoarthritis Research Society International. Pound keys (#) indicate statistical significance (###P < 0.005) relative to Sham operated group. Asterisks (*) indicate statistical significance (**P < 0.05, ***P < 0.005) comparing EU-treated groups relative to MIA injected group. : Eucommia ulmoides Prevents Articular Cartilage Destruction via FPR2-LXA4 in the Rat Monoiodoacetate Model of Osteoarthritis : Science and Education Publishing

Figure 1. Effects of Eucommia ulmoides (EU) on monoiodoacetate (MIA)-induced osteoarthritis (OA) in rats. (A) Pain behavior was assessed as mechanical hyperalgesia, measured with a dynamic plantar esthesiometer, and was quantified as paw withdrawal latency (right) (n = 10 per group). (B, C) Experimental OA was examined by scoring of OA parameters, including articular cartilage destruction (OARSI grade) (B) and safranin-O staining (C) (n = 10). Scale bar = 200 μm. Values are expressed as the mean ± SEM. One-way ANOVA was performed followed by Dunnett’s multiple comparisons test. OARSI, Osteoarthritis Research Society International. Pound keys (#) indicate statistical significance (###P < 0.005) relative to Sham operated group. Asterisks () indicate statistical significance (P < 0.05, P < 0.005) comparing EU-treated groups relative to MIA injected group.

Journal of Food and Nutrition Research. 2022, 10(4), 313-320 doi:10.12691/jfnr-10-4-8