Figure 6. The effects of lycopene on the microscopic histological appearance of livers at the end of 16 weeks of different groups. A, higher power view of the control liver showing hepatocytes arranged in single-cell plates (black arrow) with intervening blood sinusoids (yellow arrow); B, diethylnitrosamine (DEN)-treated liver tissue showing moderately pleomorphic cells with prominent nucleoli (yellow arrow), arranged in trabecular and sinusoidal patterns (red arrows), scattered abnormal mitotic figures (black arrow) with an area of necrosis (blue arrow); C, lycopene 5 mg-DEN-treated liver tissue showing an area of average liver tissue (yellow arrow), and a nodule (black arrow) showing adenomatous hyperplastic changes with no infiltrating edges (blue arrow); D, lycopene 10 mg-DEN-treated group showing moderately pleomorphic cells with prominent nucleoli (yellow arrow), arranged in trabecular (blue arrow) and sinusoidal patterns (red arrow); E, lycopene 20 mg-DEN-treated liver tissue showing markedly pleomorphic cells with prominent nucleoli (red arrow) with an area of necrosis (blue arrow). All slides were stained with H&E and the magnification power is X 400 : Ameliorative Effects of Lycopene on Diethylnitrosamine-Induced Hepatocarcinogenesis in Male Rats : Science and Education Publishing

Figure 6. The effects of lycopene on the microscopic histological appearance of livers at the end of 16 weeks of different groups. A, higher power view of the control liver showing hepatocytes arranged in single-cell plates (black arrow) with intervening blood sinusoids (yellow arrow); B, diethylnitrosamine (DEN)-treated liver tissue showing moderately pleomorphic cells with prominent nucleoli (yellow arrow), arranged in trabecular and sinusoidal patterns (red arrows), scattered abnormal mitotic figures (black arrow) with an area of necrosis (blue arrow); C, lycopene 5 mg-DEN-treated liver tissue showing an area of average liver tissue (yellow arrow), and a nodule (black arrow) showing adenomatous hyperplastic changes with no infiltrating edges (blue arrow); D, lycopene 10 mg-DEN-treated group showing moderately pleomorphic cells with prominent nucleoli (yellow arrow), arranged in trabecular (blue arrow) and sinusoidal patterns (red arrow); E, lycopene 20 mg-DEN-treated liver tissue showing markedly pleomorphic cells with prominent nucleoli (red arrow) with an area of necrosis (blue arrow). All slides were stained with H&E and the magnification power is X 400

Journal of Food and Nutrition Research. 2022, 10(4), 261-273 doi:10.12691/jfnr-10-4-2