Figures 2(A-F). Photomicrographs of the rat large intestine sections stained by HE. A&B: Micrographs from control and L-carnitine groups revealed normal structure. C: Micrograph of the large intestine in Amethopterin rat group revealed many of abnormalities as colonic epithelial cell damage in the form of epithelial separation, cellular loss (arrow heads), congestion of blood vessels, crypt hyperplasia and leukocyte infiltration (arrows). D: Micrograph of the large intestine in Co-treatment of Amethopterin rats with L-carnitine revealed more or less normal mucosal structure with a few cellular loss (arrow heads), a few inflammatory cells and mild congestion of blood vessels. E: Micrograph of the large intestine in post treatment of Amethopterin rats with L-carnitine revealed mild to moderate colonic epithelial cell damage, atrophy and mild crypt hyperplasia. F: Micrograph of the large intestine in self treatment revealed severe tissue injury as marked colonic epithelial cell damage and strong congested blood capillaries

From

The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine

Ehab Tousson, Mona Hegazy, Ezar Hafez, Alaa Abdullah Ahmed

Journal of Cancer Research and Treatment. 2014, 2(3), 55-63 doi:10.12691/jcrt-2-3-3