Abstract Aim: To compare the contribution of combined guided tissue regeneration and deproteinated bovine bone (EnterOss) and guided tissue regeneration alone to the outcomes of the treatment of infrabony defects. Materials and Methods: A total of sixteen patients of both sexes satisfying the criteria of chronic periodontitis and each of whom displayed one infrabony defect were randomly assigned to two groups, i.e. either treated with EnterOss and guided tissue regeneration (GTR) (group A) or with (GTR) alone (group B), in this parallel-arm study. The soft tissue and hard tissue measurements, including probing pocket depth (PD), clinical attachment level (CAL), and bone mineral density were recorded at baseline and 3,6 and 12 months after surgery. The differences with a P < 0.05 were considered significant. Results: Results showed that the combined group showed significant difference when compared with GTR alone, in relation to the degree of periodontal pocket, clinical attachment loss, and bone density. While in relation to Plaque and Gingival indices there is no significant difference between the two groups. Conclusion: The findings of this study suggest that, combination of deproteinated bovine bone and biocollagen membrane could be considered as an option in the treatment of infrabony defects. GTR alone gives acceptable clinical results in the treatment of infrabony defects. Combination of deproteinated bovine bone and biocollagen membrane resulted in significant clinical results in the treatment of infrabony defects.
| [1] | Consensus Report on Periodontal Diseases: Epidemiology and Diagnosis. Ann Periodontol 1996; 1: 216-222.View Article PubMed |
| [2] | Garett S: Periodontal regeneration around natural teeth. In: proceedings of the 1996 world workshop in periodontology. Ann. Peridontol; 1996, 7: 621.View Article |
| [3] | Savage A, Eaton KA, Moles DR, Needleman I. A systematic review of definitions of periodontitis and methods that have been used to identify this disease. J Clin Periodontol 2009; 36: 458-67.View Article PubMed |
| [4] | Cochran D; Inflammation and bone loss in periodontal disease. J. Periodontol, 2008. 79, 1569-1576View Article PubMed |
| [5] | American Academy of Periodontology: Parameters on chronic peridontotitis with slight to moderate loss of periodontal support. (Position Paper). J. Peridontol, 2000a; 71: 853-855.View Article PubMed |
| [6] | Thomas E. Van Dyke, D & Sheilesh Dave: J. Int Acad Periodont. 2005 Jan; 7(1): 3-7. |
| [7] | Albandar J, Streckfus C, Adesanya M& Winn D: Cigar, pipe and cigarette smoking as risk factors for periodontal disease and tooth loss. J. Periodontol 2000; 71:1874-1881.View Article PubMed |
| [8] | Hujoel P: Endpoints in periodontal trials: the need for an evidence-based research approach. Periodontol 2000, 2004; 36, 196-2004.View Article PubMed |
| [9] | Becker W, Becker B, Berg L & Samsam C: Clinical and volumetric analysis of three-wall intrabony defects following open flap debridement. J. Periodontol, 1986b.57: 277.View Article PubMed |
| [10] | Gantes B, Garrett S & Egelberg J: Treatment of periodontal furcation defects (II). Bone regeneration in mandibular class II defects. J. Clin. Periodontol, 1988; 15: 232-239.View Article |
| [11] | Cortellini P, Pini Prato G & Tonetti M: Periodontal regeneration of human intrabony defects. Clinical measures. J. of Periodontol 1993a; 64, 254-260.View Article PubMed |
| [12] | Herrera D, Sanz M, Jepsen S, Needleman I & Roldan S: A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planning in periodontitis patients. J. Clin Periodontol. 29(Supply 3)2002: 139-159.View Article |
| [13] | Essam et al; Clinical and radiographic evaluation of periodontal intrabony defects by open flap surgery alone or in combination with Biocollagen membrane. 2015, Volume 5, Issue: 3: 190-198.View Article |
| [14] | Karring T, Lindhe J, Cortellini P. Regenerative periodontal therapy. In: Lindhe J, Lang NP, Karring T, editors. Clinical Periodontology and Implant Dentistry. Copenhagen: Munksgaard; 2007. p. 597-646View Article |
| [15] | David S.H. Lee, Y. Pai, Steve Chang; Physicochemical characterization of InterOss_ and Bio-Oss_ anorganic bovine bone grafting material for oral surgery Materials Chemistry and Physics 146 (2014) 99-104.View Article |
| [16] | Richardson C, Mellonig C, Brunsvold J, McDonnell M, Cochran H. Clinical evaluation of Bio-Oss: a bovinederived xenograft for the treatment of periodontal osseous defects in humans. J. Clin. Periodontol. 1999; 26, 421-428.View Article PubMed |
| [17] | Taheri M, Molla, R., Radvar, M, Sohrabi, K., Najafi, M; An evaluation of bovine derived xenograft with and without a bioabsorbable collagen membrane in the treatment of mandibular class II furcation defects. Aust. Dent. J. 2009; 54, 220-227.View Article PubMed |
| [18] | Egelberg J; Regeneration and repair of periodontal tissues. J Periodontol Res 1987; 22:233-42.View Article PubMed |
| [19] | Karring T, Nyman S, Gottlow J, Laurell L. Development of the biological concept of guided tissue regeneration--animal and human studies. Periodontol 2000 1993; 1: 26-35.View Article |
| [20] | Araújo MG, Berglundh T, Lindhe J. GTR treatment of degree III Furcation defects with 2 different resorbable barriers. An experimental study in dogs. J Clin Periodontol 1998; 25: 253-9.View Article PubMed |
| [21] | Schüpbach P, Gaberthüel T, Lutz F, Guggenheim B. Periodontal repair or regeneration: Structures of different types of new attachment. J Periodontol Res 1993; 28: 281-93.View Article |
| [22] | Graziani L, Laurell L, Tonetti M, Gottlow J, Berglundh T. Periodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: Short-, medium-and long-term healing. J Clin Periodontol 2005; 32: 905-14.View Article PubMed |
| [23] | Nyman S, Lindhe J, Karring T, Rylander H. New attachment following surgical treatment of human periodontal disease. J Clin Periodontol 1982; 9:290-6.View Article PubMed |
| [24] | Garrett S. Periodontal regeneration around natural teeth. Ann Periodontol 1996; 1: 621-66.View Article PubMed |
| [25] | Eickholz P, Pretzl B, Holle R, Kim TS. Long-term results of guided tissue regeneration therapy with non-resorbable and bioabsorbable barriers. III. Class II furcations after 10 years. JPeriodontol2006; 77: 88-94.View Article PubMed |
| [26] | Karring T, Nyman S, Gottlow J, Laurell L, Hardwick R, Scantlebury T, et al. Development of the biological concept of guided tissue regeneration--animal and human studies. Periodontol 2000 1993; 1: 26-35.View Article |
| [27] | Hardwick R, Scantlebury T, Sanchez R, Whitley N, Ambruster J. Membrane design criteria for guided bone regeneration of the alveolar ridge. In: Buser D, Dahlin C, Schenk RK, editors. Guided Bone Regeneration in Implant Dentistry. Chicago: Quintessence; 1994. p. 101-36.View Article |
| [28] | Gottlow J. Guided tissue regeneration using bioresorbable and non-resorbable devices: Initial healing and long-term results. J Periodontol 1993; 64(Suppl):1157-65.View Article PubMed |
| [29] | Bunyaratavej P, Wang HL. Collagen membranes: A review. J Periodontol 2001; 72: 215-29.View Article PubMed |
| [30] | Loe H: The gingival index, plaque index and the retention index systems J. periodontol. 1967; 38: 610 (supplement).View Article |
| [31] | Abramson J: The cornell medical index as an epidemiological tool. AMJ, puplic health1966, 56: 287-298.View Article |
| [32] | Ramfjord S: The periodontal index, J. periodontol.1967; 38; 604-610. |
| [33] | Polson M, Yeaple R& Zande H: Histologic determination of probe tip penetration into gingival sulcus of human using an electronic pressure, sensitive probe; J. Clin. periodontol; 7; 479-488.View Article PubMed |
| [34] | Scantlebury TV. 1982-1992: A decade of technology development for guided tissue regeneration. J Periodontol 1993; 64(Suppl): 1129-37.View Article PubMed |
| [35] | Adriaens PA, Adriaens LM. Effect of nonsurgical periodontal therapy on hard and soft tissues. Periodontol 2000 2004; 36: 121-45.View Article PubMed |
| [36] | Cobb CM. Non-surgical pocket therapy: Mechanical. Ann Periodontol 1996; 1:443-90.View Article PubMed |
| [37] | Machtei EE, Dunford R, Grossi SG, Genco RJ. Cumulative of periodontal attachment loss. J Periodontal Res 1994; 29:361-4.View Article PubMed |
| [38] | Fleicher HC, Mellonig JT, Brayer WK, Gray JL, Barnett JD. Scaling and root planing efficacy in multirooted teeth. J Periodontol 1989; 60: 402-9.View Article PubMed |
| [39] | Schmitt SM, Brown FH. Management of root-amputated maxillary molar teeth: Periodontal and prosthetic considerations. J Prosthet Dent 1989; 61: 648-52.View Article |
| [40] | Lekovic V, Camargo PM, Weinlaender M, Nedic M, Aleksic Z, Kenney EB. A comparison between enamel matrix proteins used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in humans. J Periodontol 2000; 71: 1110-6.View Article PubMed |
| [41] | Karring T, Nyman S, Gottlow J, Laurell L, Hardwick R, Scantlebury T, et al. Development of the biological concept of guided tissue regeneration--animal and human studies. Periodontol 20001993; 1: 26-35.View Article |
| [42] | Joly JC, Palioto DB, de Lima AF, Mota LF, Caffesse R. Clinical and radiographic evaluation of periodontal intrabony defects treated with guided tissue regeneration. A pilot study. J Periodontol 2002; 73: 353-9.View Article PubMed |
| [43] | Trejo P, Weltman R, Caffesse R; Treatment of intraosseous defects with bioabsorbable barriers alone or in combination with decalcified freeze-dried bone allograft: A randomized clinical trial. J Periodontol 2000; 71: 1852-61.View Article PubMed |
| [44] | Rabalaise M, Yukna R, Mayer E; Evaluation of durapatite ceramic as an alloplastic implant in periodontal osseous defects. I. Initial six-month results. J Periodontol 1981; 52: 680-9.View Article PubMed |
