Figure 1. Proteolytic processing of Amyloid precursor protein (APP): APP is proteolytically processed in the extracellular and intracellular domains by β and then γ- secretase enzymes. The Amyloid plaques implicated in AD are formed by improper cleavage of the APP protein

From

Variations in Hotspot Region of β-amyloid Precursor Protein (APP) Gene in Various Neurological Disorders from Hyderabad, a Cosmopolitan City of South India

Winnie Thomas, Sireesha Divyakolu, Vemula Ramana Sreekanth, Vallomkonda Ramesh Om Sai, Vallomkonda Nagaratna, Qurratulain Hasan, Yog Raj Ahuja

International Journal of Clinical and Experimental Neurology. 2015, 3(1), 4-10 doi:10.12691/ijcen-3-1-2