Figure 4. Effect of treatment with MTX and SIL alone or their combination on TNF-α generation induced by zymosan in rats, determined by ELISA in tissue extracts of knee joints recovered 6 h after zymosan stimulation. Results are expressed as the mean± S.D. from at least 6 animals per group. Statistically significant differences (P<0.05) among groups were indicated by different letters (a,b,c,d)

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Silibinin Improves the Anti-arthritic Activity of Methotrexate in Zymosan-Induced Arthritis in Rats

Ahmed Hashem Mortada, Saad Abdulrahman Hussain

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