For children with major thalassemia, lifelong blood transfusions were need hence adequate care quality is crucial. Research aim was to improve quality of nursing care among school age children with thalassemia as regards blood transfusion and self concept. Research design: quasi-experimental design has been used. Study area: The study was done in out and inpatient pediatric unit at Minia University and General Hospitals. Study participants: purposive technique consisted of two category: the first participants are all nurses (13 Minia University nurses and 7 General Hospitals, total twenty nurse) and the second participant are fifty ill school children with thalassemia. Tools: Information were gathered by: face to face interviews questionnaire, including: sociodemographic data sheet for thalassemia, knowledge sheet for nurses and routine knowledge of blood transfusion (RBTKQ) questionnaire. (2) An observational checklist for evaluating thalassemia practices by nurses. (3) Scale of patient satisfaction. (4) The clarity scale of the self-concept. Results: This study showed significant improvements in post-test nursing knowledge and practices on thalassemia and blood transfusion and improved self-concept in clients. Conclusion: After the program was applied, about thalassemia and blood transfusion now is understandable by nurses. The nurses considered the quality of nursing care and good self-concept. The research study suggested more studies to be done for improving nurses' knowledge and practices in the area of blood transfusion care and to improve the self-concept of thalassemia children.
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