Oral drug misuses are occurring at an alarming rate; these misuses are both avoidable and expensive to the healthcare system. Study aim: The aim was to evaluate the impact of an educational program for mothers about preventing oral medications misuse for children under five years. Design: Quiz-experimental research design was used. Setting: The study was implemented at out-patient clinics in Assiut University Children Hospital. Subjects: A convenience sample of 50 mothers who had children under five years with acute common illnesses. Tools: The study used two tools: Tool I included two parts; part one; the socioeconomic scale and part two; mothers' age and main sources of information. Tool II was the structured interview questionnaire about mothers' knowledge regarding their practices during oral medications administration. Results: The majority of the mothers (88%) had a poor score of knowledge about practice before the program while 94% of them had a good score after the program. Also, the majority of them (96%, 88%, and 78%) compared to 82%, 8%, and 14% respectively in the pre and posttest gave antipyretics, cough & cold and antibiotics medications without a prescription. Conclusion: The educational program improved the mothers' knowledge about practice regarding oral medications administration for their young children and decreased oral drug misuse with a statistically significant difference between pre and posttest as regard their total score. Recommendations: Pediatric hospitals should offer the mothers with handouts, brochures, pamphlets, posters or videotapes about oral medication administration.
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