Traumatic brain injury (TBI) remains an increasingly prevalent cause of death and disability worldwide. Despite the growing evidence that supports the use of an evidence-based care bundle in the emergency department, little is known about this bundle in caring for TBI patients in Egypt. This study aimed to investigate the effect of implementing an evidence-based care bundle on the outcome of TBI patients. Design: A quasi-experimental research design was used. Setting: The study was conducted in the emergency department of the Emergency Hospital, Mansoura University in Egypt. Subjects: A convenience sample of 52 patients aged ≥ 18 years of both genders, who were admitted to the previously mentioned setting included in this study. The patients were divided into two groups: control and bundle groups, with 26 patients in each group. Tools: Data were collected using one tool: Traumatic Brain Injury Patients’ Assessment Sheet. The results: There was improvement in the bundle group patients’ GCS, pupil size and reactivity, and survival, which was statistically significant except for patients’ survival. Conclusion and Recommendations: Evidence-based care bundle improves TBI patients' outcomes. Therefore, it is recommended to use this bundle as a fundamental part of the initial nursing care for TBI patients in the emergency department.
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