Figure 1. a. Section in myocardium of control rats showing normal muscle fibers with intact myocytes and no extracellular matrix changes. b section in myocardium of DOX group showing marked degeneration and myofibrillar disarrangement, vacuolization of the cytoplasm (arrow), Myocyte loss and inflammatory cell infiltration detected (stare). c. section in myocardium of DOX + TUDCA group showing mild degeneration of muscle fibers(arrow) (H&E x400)

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Antiapototic Effect of Tauroursodeoxycholic Acid Protects against Acute Doxorubicin Induced Cardiomyopathy in Rats

Eman R. Abozaid, Amal Al-Shahat Ibrahim, Nadine A Raafat

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