In prepubertal rats, on a model of acute toxic hepatitis induced by carbon tetrachloride, some indicators of carbohydrate metabolism were studied after pharmacotherapy with Rutan and Karsil. It was established that acute toxic hepatitis is accompanied by hyperglycemia and a sharp decrease in glycogen content, along with an increase in lactic acid concentration and a decrease in pyruvic acid, which, according to the authors, indicates the development of hepatic hypoxia and lactic acidosis. Experimental therapy with Karsil and especially Rutan led to the elimination of hyperglycemia and an increase in glycogen levels, a reduction in lactic acid, and a slight increase in pyruvic acid. These changes indicate the restoration of the energy supply of hepatocytes and create favorable conditions for the course of biosynthetic processes. It is concluded that Rutan, similar to Karsil, can be used in the treatment of acute toxic hepatitis in pediatric practice.
| [1] | Maev I.V., Bordin D.S., Ilchishina T.A., Kucheryavyi Yu.A., 2021, Biliary continuum: a current view on diseases of the biliary tract. Meditsinskiy Sovet., 15, 122–134.View Article |
| [2] | Demidov V.N., Nazarenko O.A., Egorova E.Yu., et al., 2011, Efficacy of Progepar in experimental liver injury induced by alcohol and paracetamol. Farmateka., 2, 85–90. |
| [3] | Molochkova O.V., Kovalev O.B., Konev V.A., Uchaikin V.F., Snetkova Yu.S., 2017, Drug-induced hepatitis in children. Detskie Infektsii, 16, 1, 42–50.View Article |
| [4] | Peters A.L., Kim S., Mourya R., et al., 2023, Recent increase in incidence of severe acute hepatitis of unknown etiology in children is associated with infection with adenovirus and other non-hepatotropic viruses, Journal of Pediatrics, 259, 113439.View Article PubMed |
| [5] | Maslovskaya A.A., 2007, Features of carbohydrate metabolism in children, Zhurnal GrGMU, 2, 15–17. |
| [6] | Khakimov Z.Z., Rakhmanov A.Kh., Khalmuratova F.A., 2025, Effectiveness of Rutan in correcting disorders of lipid peroxidation in prepubertal rats with acute toxic hepatitis, International Journal of Medical Sciences, 5, 109–114. Available from: . |
| [7] | Khakimov Z.Z., Rakhmanov A.Kh., Khalmuratova F.A., 2025, Study of the effect of Rutan and Karsil on the absorptive-excretory function of the liver in acute toxic hepatitis during the prepubertal period, Web of Medicine: Journal of Medicine, Practice and Nursing, 3(7), 70–76. Available from: webofjournals.com/ index.php/5. |
| [8] | Khakimov Z.Z., Rakhmanov A.Kh., Khalmuratova F.A., 2025, Evaluation of the effectiveness of Rutan and Karsil in correcting antipyrine pharmacokinetics disorders in rabbits with acute toxic hepatitis during the growth period, American Journal of Pediatric Medicine and Health Sciences, 3(7), 108–112. Available from: https://grnjournal.us/index.php/AJPMHS/article/view/8164. |
| [9] | Mironov A.N., 2012, Guidelines for Conducting Preclinical Studies of Drugs. Part One, Moscow: Grif i K, 944 p. |
| [10] | Kamyshnikov V.S., 2013, Methods of Clinical Laboratory Research, Moscow: MEDpress-Inform, 736 p. |
| [11] | Danchenko E.O., Chirkin A.A., Balaeva-Tikhomirova O.M., Tolkacheva T.A., 2018, Methods of Biochemical Research Based on the Use of Specialized Equipment: Methodological Guidelines for Laboratory Work, Vitebsk: VSU named after P.M. Masherov, 51 p. |
| [12] | Kulebyakin K.Yu., Akopyan Zh.A., Kochegura T.N., Penkov D.N., 2016, Mechanisms of transcriptional control of glucose metabolism in the liver, Sakharnyi Diabet, 19(3), 190–198.View Article |
| [13] | Soon G.S.T., Torbenson M., 2023, The liver and glycogen: in sickness and in health, International Journal of Molecular Sciences, 24, 6133.View Article PubMed |
| [14] | Petrosyan E.A., Sergienko V.I., Rykunova V.E., 2017, Biotransformation of xenobiotics and endobiotics in peritonitis, Eksperimentalnaya i Klinicheskaya Gastroenterologiya, 2(138), 92–96. |
| [15] | Kim J.W., Tung H.C., Yang B., et al., 2025, Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks, Pharmacological Reviews, 77(3), 100045.View Article PubMed |
| [16] | Shun Y., Chai H., Tao T., et al., 2024, Role of lactate and lactate metabolism in liver diseases (Review), International Journal of Molecular Medicine, May 20. |
| [17] | Akramova Ya.Z., Mutanov T.B., Paizieva L.A., 2015, Glycogen-forming and detoxifying function of the liver in pathological conditions, Meditsinskiy Zhurnal Uzbekistana, 4, 114–118. |
| [18] | Khakimov Z.Z., Rakhmanov A.Kh., Mavlanov Sh.R., 2021, Effectiveness of a mixture of medicinal plant extracts in correcting disorders of liver function in various etiologies, Tashkent: O‘zkitobsavdonashriyoti, 155 p. |
| [19] | Mavlanov Sh.R., Khakimov Z.Z., Rakhmanov A.Kh., 2017, Methods for Experimental Study of the Effect of New Pharmacologically Active Compounds on the Hepatobiliary System, Tashkent, 64 p. |
| [20] | Vlasov A.P., Anaskin S.G., Vlasova T.I., et al., 2021, Systemic inflammatory response syndrome in pancreonecrosis: triggering agents and organ damage, Khirurgiya. Zhurnal im. N.I. Pirogova, 4, 21–28.View Article PubMed |
| [21] | Khakimov Z.Z., Rakhmanov A.Kh., Kurbanniyazova Yu.A., 2024, Antihypoxic and Actoprotective Activity of Plants: Glycyrrhiza glabra, Hypericum scabrum, Ziziphora pedicellata and Mediasia macrophylla, Tashkent, 124 p. |
