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Cushing Syndrome Due to Pigmented Nodular Adrenal Hyperplasia in an Iranian Patient: A Case Report and Review of the Literature

Kamyar Asadipooya1, Roohollah Narimani2, Ashraf Aminorroaya2, Bijan Iraj‬2, Mohammadreza Kalantarhormozi3,, Novin Afshar Moghadam4, Elaheh Kavoussi3, Mitra Dashtizadeh‬‬‬3

1Division of Endocrinology and Molecular Medicine, Department of Medicine, University of Kentucky, Lexington, Kentucky

2Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3Department of Internal Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, IRAN

4Department of pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IRAN

American Journal of Medical Case Reports. 2021, 9(10), 492-494. DOI: 10.12691/ajmcr-9-10-3
Received April 23, 2021; Revised May 27, 2021; Accepted June 08, 2021

Abstract

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of Adrenocorticotropic hormone-independent Cushing syndrome. In this case, we present a case of PPNAD in 25 y/o women who presented with a 3 years history of weight gain, hirsutism, and abnormal menstruation. Our findings were suggestive of PPNAD in the pathological study of adrenal biopsy.

Keywords:

Cushing syndrome, PPNAD, Primary pigmented nodular adrenocortical, hirsutism, low dose dexamethasone suppression test
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