Figure 2. Histopathology: A. Small cells with pleomorphic nuclei, and inconspicuous cytoplasm (H & E staining, magnification 10X, bar 100um). B. Small processes seen arising from tumor cells (arrow-heads) and scattered eosinophilic multinucleated giant cells (black arrow) in myxoid background (H & E staining, magnification 40X, bar 25um). C. Cells with vague strap morphology (H & E staining, magnification 40X). D. Immunohistochemistry of tumor demonstrating desmin positivity in the eosinophilic multinucleated giant cells and cells with vague strap morphology (magnification 40X, bar 25um). E. Fluorescence in situ hybridization with Vysis C-MYC break-apart probe showing C-MYC amplification with centromere 5’ MYC (flurophore spectrum orange) fused with telomere 3’ MYC (flurophore spectrum green)

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Adult Large Cell/Anaplastic Medulloblastoma with Myogenic Differentiation: Case Report with Molecular Analysis

Simin Laiq, Jaragh M, Ginsberg H, David G Munoz

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