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Adult Large Cell/Anaplastic Medulloblastoma with Myogenic Differentiation: Case Report with Molecular Analysis

Simin Laiq1,, Jaragh M2, Ginsberg H3, David G Munoz2

1Histopathology Department, Directorate General of Khoula Hospital, Muscat, Oman

2Division of Pathology, St. Michael’s Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

3Division of Neurosurgery, St. Michael’s Hospital, Department of Surgery, Toronto, Ontario, Canada

American Journal of Medical Case Reports. 2021, 9(1), 71-74. DOI: 10.12691/ajmcr-9-1-18
Received October 05, 2020; Revised November 06, 2020; Accepted November 12, 2020

Abstract

Medulloblastoma with myogenic differentiation (MMD), previously termed medullomyoblastoma, is a distinctive subtype of medulloblastoma. It is an uncommon neoplasm in children and very rare in adults, with oldest reported case being 49-years of age. We present a case of large cell/anaplastic medulloblastoma with myogenic differentiation arising in the right cerebellar hemisphere of a 54-year-old man treated by surgical resection and radiotherapy. Despite C-MYC amplification in the tumor, he survived tumor-free for nearly 2 years (726 days), which greatly exceeded the expected total survival. His death was attributed to complications of treatment rather than recurrence.

Keywords:

Large cell/anaplastic medulloblastoma with myogenic differentiation, medullomyoblastoma, cerebellum, adult, C-MYC amplification
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