Figure 3. Pathophysiology of acute kidney injury secondary to vancomycin, piperacillin-tazobactam (TZP), and methotrexate (MTX) use. AKI = acute kidney injury, MTX = methotrexate, PCT = proximal convoluted tubule, TZP = piperacillin-tazobactam

From

Nephrotoxicity Associated with Low-dose Methotrexate and Outpatient Parenteral Microbial Therapy: A Case Report, Review of the Literature and Pathophysiologic Insights

Benjamin Ramalanjaona, Gil Hevroni, Samantha Cham, Cameron Page, Moro O. Salifu, Samy I. McFarlane

American Journal of Medical Case Reports. 2020, 8(11), 400-404 doi:10.12691/ajmcr-8-11-6