Open Access Peer-reviewed

Unusual Presentation of Chronic Myeloid Leukemia as Retroperitoneal Hematoma: A Case Report

Yasir Bashir1, Fahim Manzoor2, Shuaeb Bhat2, Nusrat Bashir2,, Shabeer Ahmad3, Sajad Geelani2, Javid Rasool2

1Department of Critical Care Medicine, Sher -I -Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India

2Department of Haematology, Sher -I -Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India

3Department of General Surgery, Sher -I -Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India

American Journal of Medical Case Reports. 2014, 2(10), 227-228. DOI: 10.12691/ajmcr-2-10-8
Published online: August 25, 2017

Abstract

Chronic myeloid leukemia(CML) usually remains asymptomatic and has varied clinical presentation. The disease usually has a chronic course till it goes into blast crisis when it develops fever, other constitutional symptoms and bleeding manifestations as seen in acute leukemia. Here, we present a case that came to our emergency department as a case of acute abdomen in the form of massive retroperitoneal hematoma and subsequently proved to be a case of Philadelphia positive CML with blast crisis.

Keywords:

Chronic myeloid leukemia, retroperitoneal hematoma
[1]  D L Longo etal Harrisons principles of internal medicine, McGraw-Hill companies, 17th edition; 1; 685.
 
[2]  Kaushansky Ketal, Williams haematology, McGraw-Hill Professional Publishing, 8th edition chapter 90.
 
[3]  Kavalerchik E, Goff D, Jamieson CH. Chronic myeloid leukemia stem cells. J Clin Oncol, 26 (17).2911-2915. Jun. 2008.
 
[4]  Savona M, Talpaz M. Getting to the stem of chronic myeloid leukaemia. Nat Rev Cancer, 8 (50). 341-350. May. 2008.
 
[5]  Bhasin HK, Dana CL. Spontaneous retroperitoneal hemorrhage in chronically hemodialyzed patients. Nephron, 22 (4-6). 322-7. 1978.View Article  PubMed
 
[6]  Estivill Palleja X, Domingo P, Fontcuberta J, Felez J. Spontaneous retroperitoneal hemorrhage during oral anticoagulant therapy. Arch Intern Med, 45. 1531-4. 1981.
 
[7]  Mant MJ, O'Brien BD, Thong KL et al. Haemorrhagic complications of heparin therapy. Lancet., 1. 1133-5.1977.
 
[8]  Monib S, Ritchie A, and Thabet E. Idiopathic Retroperitoneal Hematoma. J Surg Tech Case Rep, 3 (1). 49-51. Mar. 2011.View Article  PubMed
 
[9]  Curry PVL, Bacon PA. Retroperitoneal haemorrhage and neuropathy complicating anticoagulant therapy. Postgrad Med J, 50 (579). 37-40. Jan. 1974.View Article  PubMed
 
[10]  Al-Khulaiwi A, Razaak FA, El Shair A, Bamehriz F. Idiopathic retroperitoneal hematoma. Ann Saudi Med, 20. 270-1. 2000. PubMed
 
[11]  Morgentaler A, Belville JS, Tumeh SS, Richie JP, Loughlin KR.Rational approach to evaluation and management of spontaneous perirenal hemorrhage. Surg Gynecol Obstet, 170.121-5. 1990.
 
[12]  Chang S, Ma C, Lee S. Spontaneous retroperitoneal hemorrhage from kidney causes. Eur Urol, 15. 281-4. 1988. PubMed
 
[13]  Koh KB, George J. Radiological parameters of bleeding renalangiomyolipomas. Scand J Urol Nephrol, 30. 265-8.1996.
 
[14]  van Baal JG, Smits NJ, Keeman JN, Lindhout D, Verhoef S. The evolution of renal angiomyolipomas in patients with tuberousclerosis. J Urol, 152. 35-8. 1994. PubMed