A 76-year-old male patient presented at a local medical facility with complaints of upper abdominal pain. He was subsequently referred to our hospital for emergency care due to an abdominal aneurysm, as well as leukopenia and thrombocytopenia. Upon arrival, the patient exhibited moderate fever. A physical examination revealed a flat abdomen with tenderness and recoil pain in the upper abdomen. Consequently, a comprehensive blood test revealed bicytopenia, an inflammatory reaction, abnormal glucose tolerance, and hyperlactate dehydrogenase (LDH)emia. A whole body computed tomographic scan revealed an enlarged pancreatic head and abdominal aorta with mural thrombus without significant lymph node enlargement. The patient was administered steroids under the diagnosis of hemophagocytic syndrome, resulting in the resolution of fever, a decline in LDH and CRP levels. On the 19th day, a skin biopsy revealed a diagnosis of intravascular large B-cell lymphoma (IVLBCL). Consequently, the patient underwent repeated chemotherapy. However, the patient developed multiple organ failure and died on day 74.
| [1] | Staessens S, De Beule N, Van Nedervelde E, Allard S. Intravascular Large B-cell Lymphoma Associated With Hemophagocytosis as a Cause of Fever of Unknown Origin: A Review of Literature. Cureus. 2024 Nov 10; 16(11): e73385.View Article PubMed |
| [2] | Enzan N, Kitadate A, Kono M. Optimizing random skin biopsies: a review of techniques and indications for intravascular large B-cell lymphoma. Int J Hematol. 2024 Jun; 119(6): 619-625.View Article PubMed |
| [3] | Nakamoto H, Yokota R, Namba H, Yamada K, Hosoda M, Taguchi K. Effectiveness of Intraoperative Indocyanine Green Fluorescence-Navigated Surgery for Superior Mesenteric Vein Thrombosis that Developed During Treatment for Intravascular Lymphoma: A Case Report. Am J Case Rep. 2021 Apr 30; 22: e929549.View Article PubMed |
| [4] | Zhang DD, Zhang L, Zhou J, Jiang GZ, Li P, Zhang YP, Wang GN, Zhao WG, Li WC. Clinicopathological features and MYD88 L265P mutation status of intravascular large B cell lymphoma]. Zhonghua Bing Li Xue Za Zhi. 2021 Mar 8; 50(3): 217-221. Chinese. |
| [5] | Aasfara J, Guessous F, Al Bouzidi A, Ouhabi H, Schiff D. Encephalomyeloradiculoneuropathy Revealing a Rare Case of Intravascular Large B-Cell Lymphoma.Cureus. 2021 Jan 17; 13(1): e12749.View Article |
| [6] | Atalar SC, Akay OM, Osmanbaşoğlu E, Masyan H, Taşkın OÇ, Ferhanoğlu B. Intravascular Large B-Cell Lymphoma Within the Appendix Presenting as Acute Abdomen: A Challenging Diagnosis for Hematologists.Turk J Haematol. 2021 Feb 25; 38(1): 89-91.View Article PubMed |
| [7] | Ronny FMH, Black MA, Arbini AA. Intravascular large B-cell lymphoma with multi-organ failure presenting as a pancreatic mass: a case with atypical presentation and definite diagnosis postmortem. Autops Case Rep. 2017 Dec 8; 7(4): 30-36.View Article PubMed |
| [8] | Kumar V, Soni P, Dave V, Harris J. Unusual Presentation of Diffuse Large B-Cell Lymphoma with Splenic Infarcts. J Investig Med High Impact Case Rep. 2017 Feb 1; 5(1): 2324709617690748.View Article PubMed |
| [9] | Crane GM, Ambinder RF, Shirley CM, Fishman EK, Kasamon YL, Taube JM, Borowitz MJ, Duffield AS. HHV-8-positive and EBV-positive intravascular lymphoma: an unusual presentation of extracavitary primary effusion lymphoma. Am J Surg Pathol. 2014 Mar; 38(3): 426-32.View Article PubMed |
| [10] | Ishii W, Ito S, Kondo Y, Tsuboi H, Mamura M, Goto D, Matsumoto I, Tsutsumi A, Sumida T, Okoshi Y, Hasegawa Y, Kojima H, Sakashita S, Aita K, Noguchi M.J Clin Oncol. 2008 Mar 20; 26(9):1553-5.View Article PubMed |
| [11] | Kröber SM. ntravascular lymphoma causing acute abdomen.Pathologe. 2007 Feb; 28(1): 51-4.View Article PubMed |
| [12] | Williams G, Foyle A, White D, Greer W, Burrell S, Couban S.Am J Hematol. 2005 Mar; 78(3): 207-11.View Article PubMed |
| [13] | Enzan N, Kitadate A, Kono M. Optimizing random skin biopsies: a review of techniques and indications for intravascular large B-cell lymphoma. Int J Hematol. 2024 Jun; 119(6): 619-625.View Article PubMed |
| [14] | Matsue K, Abe Y, Kitadate A, Miura D, Narita K, Kobayashi H, et al. Sensitivity and specifcity of incisional random skin biopsy for diagnosis of intravascular large B-cell lymphoma. Blood. 2019; 133: 1257-9.View Article PubMed |
| [15] | Sumi-Mizuno M, Fukunaga A, Kosaka H, Imai Y, Nagano T. Appropriate indication and procedure for random skin biopsy in the diagnosis of intravascular large B-cell lymphoma. Australas J Dermatol. 2021; 62: 225-7.View Article PubMed |