Figure 2. Images of primary CNS ALK-negative anaplastic large cell lymphoma. Brain lesion resection shows fragments of brain tissue with multifocal and perivascular infiltrates of medium to large-sized malignant cells, some with multilobate/multiple nuclei (A and B). They are mitotically active highlighted by Ki67(C), positive for CD30 (D), CD4 (E), MUM1 (F), TIA1 (G), and Granzyme B (H), and negative for ALK (I), EBV (J), CD19 (K), and CD79a (L). TIA1: T-cell intranuclear antigen 1

From

Primary Central Nervous System ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report and Literature Review

Yujie Zhang, Fatemeh Fekrmandi, Jingxin Qiu

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