Figure 3. Hypothetical putative pathways depicting the intertwined signaling crosstalk between the MAPKp38 and NF-κB pathways. The involvement of upstream and downstream kinases in regulating either pathway is also shown. In addition, the selective inhibition of the MAPKp38 pathway attenuated the release of pro-inflammatory cytokines, however, it contributes to phosphorylation of IκB-α and subsequent NF-κB activation (see Results section for further details)


The Irreversible Inhibition of the MAPKp38 Pathway Downregulates LPS-augmented Release of Interleukin-Related Inflammatory Cytokines (IL-1β, IL-6): Immune Surveillance Unraveling IκB-α/NF-κB Phosphorylation State-independent Mechanism in vitro

John J Haddad

American Journal of Medical and Biological Research. 2015, 3(5), 133-138 doi:10.12691/ajmbr-3-5-3