Synchronous Primary Malignancies of the Kidney and Colon: A Rare Case

Mazaher Ramezani, Setareh Afzali, Masoud Sadeghi

American Journal of Cancer Prevention

Synchronous Primary Malignancies of the Kidney and Colon: A Rare Case

Mazaher Ramezani1, Setareh Afzali2, Masoud Sadeghi3,

1Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract

The coexistent diagnosis of colorectal cancer and renal cell carcinoma is rare. We reported a 55-year-old woman with history of recurrent UTI, who was admitted to Urology Clinic with left flank pain for the evaluation of renal stone. Ultrasound examination revealed a homogenous mass measuring 4.7cm with a calcified focus in left kidney. Macroscopic evaluation revealed a renal mass in lower pole, 5cm in maximum diameter with variegated cut surface. The pathology report showed clear cell carcinoma of kidney. The patient had a colonoscopy report of many polyps in the entire length of colon with a clinical impression of familial adenomatous polyposis since last year but with no genetic confirmatory tests Since last year, the pathology report showed well differentiated adenocarcinoma of colon invading to submucosa with no vascular and perineural invasion in the distal margin of colon. In family history, her passed brother had colon cancer and her sister was alive with colon cancer that had a colostomy. In summary, the existence of both kidney and colon cancers occurs more in elderly patients. Also, the existence of colon adenocarcinoma with numerous polyps can be a risk factor for the second malignancy that the physicians must pay attention to this point in their follow-up.

Cite this article:

  • Mazaher Ramezani, Setareh Afzali, Masoud Sadeghi. Synchronous Primary Malignancies of the Kidney and Colon: A Rare Case. American Journal of Cancer Prevention. Vol. 4, No. 4, 2016, pp 51-53. http://pubs.sciepub.com/ajcp/4/4/1
  • Ramezani, Mazaher, Setareh Afzali, and Masoud Sadeghi. "Synchronous Primary Malignancies of the Kidney and Colon: A Rare Case." American Journal of Cancer Prevention 4.4 (2016): 51-53.
  • Ramezani, M. , Afzali, S. , & Sadeghi, M. (2016). Synchronous Primary Malignancies of the Kidney and Colon: A Rare Case. American Journal of Cancer Prevention, 4(4), 51-53.
  • Ramezani, Mazaher, Setareh Afzali, and Masoud Sadeghi. "Synchronous Primary Malignancies of the Kidney and Colon: A Rare Case." American Journal of Cancer Prevention 4, no. 4 (2016): 51-53.

Import into BibTeX Import into EndNote Import into RefMan Import into RefWorks

At a glance: Figures

1. Introduction

Although cancers of the rectum and kidney are common malignancies, but the incidence of coexistent rectal and renal primary tumors is unclear [1]. Renal cell carcinoma (RCC), in particular, is associated with a high rate of multiple primary neoplasms [2]. The coexistent is rare for patients to be diagnosed with both colorectal cancer (CRC) and RCC [3, 4]. This coexistent is variously reported with percentages ranging from very rare findings (<0.1%) up to 5% of patients with CRC [5]. The diagnosis of simultaneous tumors is facilitated by the wide spread use of ultrasonography, computed tomography or magnetic resonance imaging techniques. The possibility of coexisting asymptomatic RCC and CRC suggests the need to perform imaging studies when one of the two tumors is diagnosed [6]. We reported synchronous primary malignancies of the kidney and colon in an Iranian patient.

2. Case Report

A 55-year-old woman with history of recurrent UTI was admitted to Urology Clinic with left flank pain for the evaluation of renal stone. There was no hematuria. Ultrasound examination on 21st February 2016 revealed a homogenous mass measuring 47mm with a calcified focus in left kidney. The CT-scan on 7th March 2016 revealed a solid mass in the antrolateral side of left lower kidney measuring 41*42mm with obvious enhancement. On 12th April 2016, partial nephrectomy was done. Macroscopic evaluation revealed a renal mass in lower pole, 5cm in maximum diameter with variegated cut surface. The diagnosis on frozen section was RCC with 3mm safe margin. Permanent diagnosis was RCC, clear cell type with a Fuhrman nuclear grade of 2/4. Tumor was limited to renal capsule with no vascular invasion (Figure 1). The patient had a colonoscopy report of many polyps in the entire length of colon with a clinical impression of familial adenomatous polyposis (FAP) last year, but with no genetic confirmatory test. On 25th April 2015, the pathology report of colonoscopic biopsy was a villous adenomatous polyp with high grade dysplasia suspicious for malignant transformation. On 11th May 2015, resection of the colon and terminal ileum was done, gross examination showed segments of colon (74*2cm), terminal ileum (11*1cm) and appendix (5*0.7cm). On opening, the colon showed multiple sessile and pedunculated polyps (more than 50) that the greatest was 2cm. The pathology report showed well differentiated adenocarcinoma of colon invading to submucosa with no vascular and perineural invasion in the distal margin of colon. Other histological findings were numerous adenomatous polyps (more than 50) and one tubulovillous polyp with intramucosal carcinoma. Proximal margin, appendix, ileum and fifteen lymph nodes showed no tumoral involvement. The patient had a past history of hysterectomy 10 years ago, but the pathology report was not available. In family history, her passed brother had colon cancer and her sister was alive with colon cancer who had a colostomy. Three daughters and one son of the patient had no problem.

Figure 1. Renal cell carcinoma,clear cell type, [H&E Staining, A-X40, B-X100,C-X200, D-X400 magnification]

3. Discussion

The concomitant presence of RCC with other primary malignancies including cancers of bladder, prostate, colorectal, lung, malignant melanoma of skin and non-Hodgkin's lymphoma has been reported [7]. Patients with CRC and RCC may be at risk for additional primary malignancies [4]. One study [8], encountered 18 patients during a 6-year period with a urologic cancer and another primary malignancy. Thirteen patients had their second cancer detected during the work-up of their primary urologic tumor. During the 10-year period in another study [1], there were 182 patients presenting for treatment of rectal carcinoma. Of these seven (3.8%) were found to have an asymptomatic RCC. Table 1 shows the characteristics of patients with both kidney and colon cancers. The existence of both cancers occurs more in elderly patients that is more in men. The site of involvement and type of kidney and colon cancers are different. More cases didn’t report tests of genetic and therefore we couldn’t find effect of genetic in synchronous incidence of malignancies of kidney and colon.

4. Conclusion

The existence of both kidney and colon cancers occurs more in elderly patients. Also, the existence of colon adenocarcinoma with numerous polyps can be a risk factor for the second malignancy that the physicians must pay attention to this point in their follow-up.

Table 1. The characteristics of patients with both kidney and colon cancers

Competing Interests

The authors have no conflict of interests to disclose.

References

[1]  Cullinane CA, Jarrahy R, Wilson TG, Ellenhorn JD. Asymptomatic renal neoplasms in the rectal cancer patient. Am Surg. 2001; 67(12):1162-4.
In article      PubMed
 
[2]  Bhargava A, O'Callaghan M, Abdelhafiz T, Downey P, Nasr A, Nibhraonain S, et al. Synchronous sigmoid and caecal cancers together with a primary renal cell carcinoma. Ir J Med Sci. 2012; 181(2):273-6.
In article      View Article  PubMed
 
[3]  Amoroso A, Del Porto F, Garzia P, Ilardi M, Clemenzia C, D'Amato A, et al. The infrequent association of synchronous renal and colonic malignancies. Eur Rev Med Pharmacol Sci. 1999; 3(3): 111-4.
In article      PubMed
 
[4]  Steinhagen E , Moore HG, Lee-Kong SA, Shia J, Eaton A, Markowitz AJ, et al. Patients with colorectal and renal cell carcinoma diagnoses appear to be at risk for additional malignancies. Clin Colorectal Cancer. 2013;12(1):23-7.
In article      View Article  PubMed
 
[5]  Calderwood AH, Huo D, Rubin DT. Association between colorectal cancer and urologic cancers. Arch Intern Med 2008;168:1003-9.
In article      View Article  PubMed
 
[6]  Fazzin M, Dellachiesa L, Resta G, Bandi M, Marino S, Anania G. One-stage laparoscopic procedure for a patient with bilateral colorectal tumours and renal carcinoma. G Chir. 2013;34(4):132-4.
In article      PubMed  PubMed
 
[7]  Czene K, Hemminki K. Kidney cancer in the Swedish Family Cancer Database: familial risks and second primary malignancies. Kidney Int.2002;61(5):1806-13.
In article      View Article  PubMed
 
[8]  Mydlo JH, Gerstein M. Patients with urologic cancer and other nonurologic malignancies: analysis of a sample and review of the literature. Urology. 2001;58(6):864-9.
In article      View Article
 
[9]  D'Amato A, Gentili V, Santella S, Pronio A, Montesani C. [Synchronous neoplasms of the colon and kidney: analysis of 2 case reports]. Chir Ital. 2000;52(1):83-6.
In article      PubMed
 
[10]  Papalampros AE, Petrou AS, Mantonakis EI, Evangelou KI, Giannopoulos LA, Marinos GG, et al. Coexistence of a colon carcinoma with two distinct renal cell carcinomas: a case report. J Med Case Rep. 2011;5:134.
In article      View Article  PubMed
 
[11]  Kozokic A, Surlin V, Petrovic B, Petrovic V, Prvanovic G, Beraru I, et al. Considerations upon a case of synchronous primary malignancies: adenocarcinoma of the sigmoid and clear cell carcinoma of the right kidney. Rom J Morphol Embryol. 2011; 52(1 Suppl): 509-11.
In article      PubMed
 
[12]  Ahmadnia H, Molaei M. Concomitant presence of renal cell carcinoma and adenocarcinoma of the colon. Saudi J Kidney Dis Transpl. 2009;20(6):1081-2.
In article      PubMed
 
[13]  Turati L, Steccanella F , Petrelli F , Vitali E , Barni S , Sgroi G . Signet-ring cell carcinoma of the rectum and synchronous renal cell carcinoma in a young man. Int J Colorectal Dis. 2016; 31(5): 1071-2.
In article      View Article  PubMed
 
[14]  Spajić B, Grubisić I, Spajić M, Marusić Z, Demirović A, Mijić A, et al. Synchronous rectal adenocarcinoma and bilateral clear cell renal carcinoma. Acta Clin Croat. 2010;49(2):169-72.
In article      PubMed
 
[15]  Martin Arnau AB, Ochoa Vargas C, Peña Gonzalez JA, Targarona Soler EM. Simultaneous colectomy and nephectomy in synchronic tumours. Cir Esp. 2015;93(4):266-8.
In article      View Article  PubMed
 
[16]  Dafashy TJ, Ghaffary CK, Keyes KT, Sonstein J. Synchronous Renal Cell Carcinoma and Gastrointestinal Malignancies. Case Rep Urol. 2016;2016:7329463.
In article      View Article
 
  • CiteULikeCiteULike
  • MendeleyMendeley
  • StumbleUponStumbleUpon
  • Add to DeliciousDelicious
  • FacebookFacebook
  • TwitterTwitter
  • LinkedInLinkedIn