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Evaluation of the Factors Associated with Lipid Metabolism and the Response to Treatment in Type 2 Diabetic Patients Monitored at CHD-Atacora (Benin)

Tinéponanti B.T. Véronique1, 2, Chabi Nicodème Worou1, 3,, Sognigbé G. Basile1, 4, Adam Alassane2, Akpovi D. Casimir3, Sina Haziz4, Kohonou N. Arnaud1, 4, Baba-Moussa Lamine4

1Laboratoire de Biochimie et de Biologie Moléculaire, Department de Biochimie et de Biologie Cellulaire, Faculté des Sciences et Techniques, Université d’Abomey-Calavi, Bénin

2Service de diabètologie, Centre Hospitalier Départemental de l’Atacora, Bénin

3Laboratoire de Recherche en Biologie Appliquée, Ecole Polytechnique d’Abomey-Calvi, Université d’Abomey-Calavi, Bénin

4Laboratoire de Biologie et de Typage Moléculaire en Microbiologie, Département de Biochimie et de Biologie Cellulaire, Faculté des Sciences et Techniques, Université d’Abomey-Calavi, Bénin

American Journal of Biomedical Research. 2019, 7(2), 38-43. DOI: 10.12691/ajbr-7-2-3
Received October 18, 2019; Revised November 26, 2019; Accepted December 17, 2019

Abstract

Non-insulin-dependent diabetes mellitus (NIDDM) is a multifactorial disease resulting from the interaction of genetic and environmental factors. The aim of this study was to evaluate the factors associated with lipid metabolism and treatment response in type 2 diabetic patients monitored at CHD-Atacora (Benin). A total of 200 diabetic patients were included in the study. 121 women and 79 men into two groups; namely 132 had hyperglycemia and 68 in normoglycemia. Diabetics had a mean BMI of 27.95 kg / m2 while normoglycemic subjects had a BMI of 24.84 kg / m2. In addition, diabetic subjects had an average triglyceride level of 2.28 mmol / L whereas subjects with normoglycemia had an average triglyceride level of 1.04 mmol / L. Oral antibiotics did not have a significant effect on lipid metabolism and glycemic control. Eating habits were similar in both groups and did not respond to a balanced diet. The results of our study reveal that triglyceride levels and BMI are a factor influencing the glycemic status of diabetic subjects. Low levels of BMI and triglyceride levels promote good glycemic control in diabetic patients monitored in the diabetic department of CHD-Atacora.

Keywords:

type 2 diabetes, dyslipidemia, metformin, glibenclamide, Atacora, Benin
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