Figure 3. The inhibition of α-MSH- and Forskolin- induced cAMP production with the increase in the concentration of coumarin treatment. B16 cells were preincubated with various concentrations of coumarin for 5min, then cells were stimulated with α-MSH (100nM, white bar) and forskolin(100nM, closed bar), respectively. The data are the mean±S.E.M. of assay triplicates with at least six independent experiments. (**p < 0.05).

From

Coumarin, a Lead Compound of Warfarin, Inhibits Melanogenesis via Blocking Adenylyl Cyclase

Dong-Chan Kim, Seong-Hwan Rho, Dongjin Kim, Sung In Kim, Chul-Soo Jang, Jae Ki Ryu, Byung Weon Kim, Chang Oh Kweon, Hyun-kyung Kim, Suk Jun Lee

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